Basic information Safety Supplier Related

Mal-PEG4-Val-Cit-PAB-PNP

Basic information Safety Supplier Related

Mal-PEG4-Val-Cit-PAB-PNP Basic information

Product Name:
Mal-PEG4-Val-Cit-PAB-PNP
Synonyms:
  • Mal-PEG4-Val-Cit-PAB-PNP
  • L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
  • 4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl (4-nitrophenyl) carbonate
  • 4-((17S,20S)-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosan-21-amido)benzyl (4-nitrophenyl) carbonate
CAS:
2112738-09-5
MF:
C40H53N7O15
MW:
871.89
Product Categories:
  • Linker
  • ADC LINKER
Mol File:
2112738-09-5.mol
More
Less

Mal-PEG4-Val-Cit-PAB-PNP Chemical Properties

solubility 
Soluble in DMSO, DMF
form 
Solid
color 
Light yellow to yellow
More
Less

Mal-PEG4-Val-Cit-PAB-PNP Usage And Synthesis

Description

Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG space improve compound's aqueous solubility. PNP is a good leaving group.

Biological Activity

Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

Mal-PEG4-Val-Cit-PAB-PNPSupplier

Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com
Zhengzhou Huiju Chemical Co., Ltd.
Tel
0371-55900031 18137872243
Email
2853979815@qq.com
Aikon International Limited
Tel
025-66113011 18112977050
Email
sales01@aikonchem.com
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com