Mal-PEG4-Val-Cit-PAB-PNP
Mal-PEG4-Val-Cit-PAB-PNP Basic information
- Product Name:
- Mal-PEG4-Val-Cit-PAB-PNP
- Synonyms:
-
- Mal-PEG4-Val-Cit-PAB-PNP
- L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
- 4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl (4-nitrophenyl) carbonate
- 4-((17S,20S)-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosan-21-amido)benzyl (4-nitrophenyl) carbonate
- CAS:
- 2112738-09-5
- MF:
- C40H53N7O15
- MW:
- 871.89
- Product Categories:
-
- Linker
- ADC LINKER
- Mol File:
- 2112738-09-5.mol
More
Less
Mal-PEG4-Val-Cit-PAB-PNP Chemical Properties
- solubility
- Soluble in DMSO, DMF
More
Less
Mal-PEG4-Val-Cit-PAB-PNP Usage And Synthesis
Description
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG space improve compound's aqueous solubility. PNP is a good leaving group.
Biological Activity
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC).
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
|
Mal-PEG4-Val-Cit-PAB-PNPSupplier
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
Zhengzhou Huiju Chemical Co., Ltd.
- Tel
- 0371-55900031 18137872243
- 2853979815@qq.com
Aikon International Limited
- Tel
- 025-66113011 18112977050
- sales01@aikonchem.com
Xi'an Confluore Biological Technology Co., Ltd.
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
Jinan Kabotang Biological Technology Co.,Ltd.
- Tel
- 0531-61320525 15866703830
- 495745175@qq.com