Mal-PEG4-Val-Cit-PAB-PNP
Mal-PEG4-Val-Cit-PAB-PNP Basic information
- Product Name:
- Mal-PEG4-Val-Cit-PAB-PNP
- Synonyms:
-
- Mal-PEG4-Val-Cit-PAB-PNP
- L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
- 4-((17S,20S)-1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosanamido)benzyl (4-nitrophenyl) carbonate
- 4-((17S,20S)-1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosan-21-amido)benzyl (4-nitrophenyl) carbonate
- 4-[[(2S)-5-(Carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[2-[2-(2,5-dioxo-1-pyrrolyl)ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-Nitrophenyl) Carbonate
- CAS:
- 2112738-09-5
- MF:
- C40H53N7O15
- MW:
- 871.89
- Product Categories:
-
- Linker
- ADC LINKER
- Mol File:
- 2112738-09-5.mol
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Mal-PEG4-Val-Cit-PAB-PNP Chemical Properties
- storage temp.
- -20°C, protect from light
- solubility
- Soluble in DMSO, DMF
- form
- Solid
- color
- Light yellow to yellow
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Mal-PEG4-Val-Cit-PAB-PNP Usage And Synthesis
Description
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PEG space improve compound's aqueous solubility. PNP is a good leaving group.
Biological Activity
Mal-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC).
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
|
Mal-PEG4-Val-Cit-PAB-PNPSupplier
Beijing Ouhe Technology Co., Ltd
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Beijing Jin Ming Biotechnology Co., Ltd.
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Zhengzhou Huiju Chemical Co., Ltd.
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Aikon International Limited
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Xi'an Confluore Biological Technology Co., Ltd.
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