Mal-PEG4-amine TFA salt CAS#: 2512227-13-1

Mal-PEG4-amine TFA salt Basic information

Product Name:

Mal-PEG4-amine TFA salt

Synonyms:

Mal-PEG4-C2-NH2 TFA
Mal-PEG5-amine
1-(14-amino-3,6,9,12-tetraoxatetradecyl)pyrrolidine-2,5-dione 2,2,2-trifluoroacetate

CAS:

2512227-13-1

MF:

C16H25F3N2O8

MW:

430.38

Mol File:

2512227-13-1.mol

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Mal-PEG4-amine TFA salt Usage And Synthesis

Biological Activity

Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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