Mal-PEG6-NHS ester Chemical Properties

Boiling point:

635.8±65.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DCM

pka

-2.34±0.20(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C23H34N2O12/c26-19-1-2-20(27)24(19)6-8-32-10-12-34-14-16-36-18-17-35-15-13-33-11-9-31-7-5-23(30)37-25-21(28)3-4-22(25)29/h1-2H,3-18H2

InChIKey

UUNUCVXNAHYFJP-UHFFFAOYSA-N

SMILES

C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O

Mal-PEG6-NHS ester Usage And Synthesis

Description

Mal-PEG6-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-PEG6-NHS ester is a nonclaevable ADC linker containing a Maleimide group, 6-unit PEG and a NHS ester.

IC 50

Non-cleavable Linker

References

[1] Kennett Sprog?e , et al. Relaxin prodrugs. WO2015067791A1.

Mal-PEG6-NHS ester(1599472-25-9)Related Product Information

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