Mal-PEG6-COOH Chemical Properties

Boiling point:

702.5±60.0 °C(Predicted)

Density 

1.241±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

4.28±0.10(Predicted)

form 

Solid

color 

Off-white to gray

InChI

InChI=1S/C22H36N2O11/c25-19(3-6-24-20(26)1-2-21(24)27)23-5-8-31-10-12-33-14-16-35-18-17-34-15-13-32-11-9-30-7-4-22(28)29/h1-2H,3-18H2,(H,23,25)(H,28,29)

InChIKey

WKTGEZMXNNBFEZ-UHFFFAOYSA-N

SMILES

C(O)(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O

Mal-PEG6-COOH Usage And Synthesis

Description

Mal-amido-PEG6-acid is a PEG linker containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

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