Azido-PEG2-NHS ester Chemical Properties

storage temp. 

Storage temp. -20°C

solubility 

Soluble in DMSO, DMF, DCM

form 

Liquid

color 

Colorless to light yellow

Safety Information

HS Code 

2942000090

Azido-PEG2-NHS ester Usage And Synthesis

Description

Azido-PEG2-NHS ester is a click chemistry crosslinker containing an azide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

N3-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG2-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Non-cleavable Linker

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