Azido-PEG3-NHS ester Chemical Properties

storage temp. 

Storage temp. -20°C

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C13H20N4O7/c14-16-15-4-6-22-8-10-23-9-7-21-5-3-13(20)24-17-11(18)1-2-12(17)19/h1-10H2

InChIKey

BNLXVOZUEBSSRI-UHFFFAOYSA-N

SMILES

O(N1C(CCC1=O)=O)C(=O)CCOCCOCCOCCN=[N+]=[N-]

Safety Information

HS Code 

2933998090

Azido-PEG3-NHS ester Usage And Synthesis

Description

Azido-PEG3-NHS ester is a azide linker used on click chemistry. The azide group can react with alkyne such as BCN, DBCO, Propargyl group via Click Chemistry to yield a stable triazole linkage. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

N3-PEG3-C2-NHS ester is a nonclaevable 3-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Non-cleavable Linker

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