Mal-PEG1-acid
Mal-PEG1-acid Basic information
- Product Name:
- Mal-PEG1-acid
- Synonyms:
-
- Mal-PEG1-acid
- Mal-PEG1-CH2CH2COOH
- 3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid
- Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-
- Mal-PEG1-CH2CH2COOH/Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-
- 3-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]propanoic Acid
- 3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoic acid
- CAS:
- 760952-64-5
- MF:
- C9H11NO5
- MW:
- 213.19
- Mol File:
- 760952-64-5.mol
Mal-PEG1-acid Chemical Properties
- Boiling point:
- 419.4±30.0 °C(Predicted)
- Density
- 1.383±0.06 g/cm3(Predicted)
- pka
- 4.27±0.10(Predicted)
- form
- Solid
- color
- White to off-white
Mal-PEG1-acid Usage And Synthesis
Description
Mal-PEG1-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Mal-PEG1-acid is a non-cleavable ADC linker containing 1 unit PEG, which can be used to synthesize antibody drug conjugates (ADC),it is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| PEGs
| Non-cleavable
|
Mal-PEG1-acidSupplier
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- 028-84502008 13568869383
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Mal-PEG1-acid(760952-64-5)Related Product Information
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- Mal-PEG5-CH2CH2Mal
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- Mal-PEG4-amine TFA salt
- Mal-PEG4-propargyl
- Mal-PEG5-acid
- Mal-PEG3-NHS ester
- Mal-PEG6-COOH
- 2,5-Dioxopyrrolidin-1-yl 3-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)propanoate
- Mal-PEG1-Val-Cit-PAB-PNP
- Mal-PEG1-t-butyl ester
- Mal-amido-PEG1-acid
- 1-(2-HYDROXY-ETHYL)-PYRROLE-2,5-DIONE