Basic information Safety Supplier Related

Mal-PEG1-acid

Basic information Safety Supplier Related

Mal-PEG1-acid Basic information

Product Name:
Mal-PEG1-acid
Synonyms:
  • Mal-PEG1-acid
  • Mal-PEG1-CH2CH2COOH
  • 3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid
  • Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-
  • Mal-PEG1-CH2CH2COOH/Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-
  • 3-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]propanoic Acid
  • 3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoic acid
CAS:
760952-64-5
MF:
C9H11NO5
MW:
213.19
Mol File:
760952-64-5.mol
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Mal-PEG1-acid Chemical Properties

Boiling point:
419.4±30.0 °C(Predicted)
Density 
1.383±0.06 g/cm3(Predicted)
pka
4.27±0.10(Predicted)
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Mal-PEG1-acid Usage And Synthesis

Description

Mal-PEG1-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Mal-PEG1-acid is a non-cleavable ADC linker containing 1 unit PEG, which can be used to synthesize antibody drug conjugates (ADC),it is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Non-cleavable

Mal-PEG1-acidSupplier

Wuhan Brin Technology Co., Ltd. Gold
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3456065315 13260619011
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3456065315@qq.com
Hygeia (Chengdu) pharmaceutical technique Co., Ltd
Tel
028-84502008 13568869383
Email
sales@hygeiapharm.com
Jinan elephant international trading co., LTD
Tel
Email
13006575422@163.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Email
info@amateksci.com
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Mal-PEG1-acid(760952-64-5)Related Product Information