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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE

Basic information Safety Supplier Related

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Basic information

Product Name:
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
Synonyms:
  • GBR 12935 dihydrochloride, >=98%
  • GBR 12935 (hydrochloride)
  • GBR 12935 DIHYDROCHLORIDE
  • 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
  • GBR-12935 2HCL
  • GBR 12935 HCl
  • 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
  • Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2)
CAS:
67469-81-2
MF:
C28H35ClN2O
MW:
451.05
Product Categories:
  • Inhibitors
Mol File:
67469-81-2.mol
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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Chemical Properties

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
H2O: 20 mg/mL with warming
form 
powder
color 
white
Water Solubility 
H2O: 20mg/mL (with warming)
InChI
InChI=1S/C28H34N2O.ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;/h1-9,11-12,14-17,28H,10,13,18-24H2;1H
InChIKey
YMGXBGVMAOTRFZ-UHFFFAOYSA-N
SMILES
C(C1C=CC=CC=1)(C1C=CC=CC=1)OCCN1CCN(CCCC2C=CC=CC=2)CC1.Cl
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Safety Information

WGK Germany 
3

MSDS

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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Usage And Synthesis

Uses

A very potent and selective inhibitor of dopamine uptake

Definition

ChEBI: A hydrochloride salt that is obtained by reaction of 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine with two equivalents of hydrogen chloride. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal memb anes).

Biochem/physiol Actions

GBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.

in vivo

GBR 12935 dihydrochloride (1-32 mg/kg; repeat injection; 7 d) elevates locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice, and (10 mg/kg; injection; 7 d) results few mice sensitized to cocaine-induced stereotypy with repeated injections[3].

Animal Model:Adult male DBA/2J and C57BL/6J mice (22-30 g)[3]
Dosage:1.0, 3.2, 10, 32 mg/kg
Administration:Repeat injection; for 7 days
Result:Elevated locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice.
No stereotypy was induced by an eighth day challenge of 10 mg/kg GBR 12935 dihydrochloride in mice pretreated with seven dally injections of either 32 mg/kg cocaine or saline.

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDESupplier

Jingmo (Xiamen) Biotechnology Co., Ltd Gold
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821-50328103-801 18930552037
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ZHIWE CHEMTECH CO LTD
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021-20221225 13917446399
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
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cfzhang@aikonchem.com
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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE(67469-81-2)Related Product Information