1-(2-Methoxyethyl)piperazine Chemical Properties

Melting point:

100-101 °C

Boiling point:

193-194 °C (lit.)

Density 

0.970 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.4730(lit.)

Flash point:

188 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

9.15±0.10(Predicted)

form 

Liquid

color 

Clear colorless to yellow

BRN 

105098

InChIKey

BMEMBBFDTYHTLH-UHFFFAOYSA-N

CAS DataBase Reference

13484-40-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36/37/38

Safety Statements 

26-36/37/39-45-37/39

RIDADR 

UN 2735 8/PG 3

WGK Germany 

3

F 

10-34

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29349990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

1-(2-Methoxyethyl)piperazine Usage And Synthesis

Chemical Properties

Clear colorless to yellow liquid

Uses

Reactant for:• ;Preparation of biologically and pharmacologically active molecules1,2,3,4,5

Uses

Reactant for:

• Preparation of biologically and pharmacologically active molecules

Synthesis

Under nitrogen protection, 8.6 g (0.1 mol) of piperazine and 10.4 g of methanol were added to the reaction flask, 35 µl of hydrochloric acid (10.4 g, 0.1 mol) was added with stirring, and the internal temperature was controlled to 80 °C. Under the condition of keeping the internal temperature below 80 °C, 8.7 g (0.07 mol) of 2-bromoethanol was added slowly and dropwise over 0.5 h. Subsequently, the reaction was continued with stirring at the same temperature for 8 h. 36.9 g of colorless and transparent reaction solution was obtained. Gas chromatographic analysis showed a yield of 84.6% for N-(2-hydroxyethyl)piperazine, with a selectivity of 88.5% for N-(2-hydroxyethyl)piperazine, 7.7% for N,N'-bis(2-hydroxyethyl)piperazine, and 3.8% for the unknown component. Compared to the results of Example 2 in Table 1 , the reaction conditions were the same as in Example 2 when 3.8 g (0.04 mol) of 2-methoxyethyl ester was used in place of 2-bromoethanol. GC analysis showed a 70.1% yield of N-(2-methoxyethyl)piperazine with a selectivity of 83.4% for N-(2-methoxyethyl)piperazine, 15.0% for N,N'-bis(2-methoxyethyl)piperazine, and 1.6% for the unknown component. This result is consistent with the results of Example 5 in Table 1.

References

[1] Patent: JP5838628, 2016, B2. Location in patent: Paragraph 0056; 0059

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