1-Hydroxyethylethoxypiperazine Chemical Properties

Boiling point:

112-114 °C0.25 mm Hg(lit.)

Density 

1.061 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.497(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

pka

14.41±0.10(Predicted)

Specific Gravity

1.061

color 

Clear colorless to yellow-brownish

InChI

InChI=1S/C8H18N2O2/c11-6-8-12-7-5-10-3-1-9-2-4-10/h9,11H,1-8H2

InChIKey

FLNQAPQQAZVRDA-UHFFFAOYSA-N

SMILES

C(O)COCCN1CCNCC1

CAS DataBase Reference

13349-82-1(CAS DataBase Reference)

NIST Chemistry Reference

1-(2-(2-Hydroxyethoxy)ethyl)piperazine(13349-82-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29335990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

1-Hydroxyethylethoxypiperazine Usage And Synthesis

Chemical Properties

Yellow-Brown Oil

Uses

1-[2-(2-Hydroxyethoxy)ethyl]piperazine may be used in chemical synthesis.

Uses

Quetiapine intermediate

Definition

ChEBI: 1-(2-(2-Hydroxyethoxy)ethyl)piperazine is a N-alkylpiperazine.

Synthesis

The general procedure for the synthesis of 1-[2-(2-hydroxyethoxy)ethyl]piperazine from the compound (CAS:166388-52-9) was as follows: 54.2 g of compound 3 was dissolved in 300 mL of dichloromethane, followed by the addition of 26 g of trifluoroacetic acid. The reaction mixture was stirred at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was complete. After completion of the reaction, 1 N NaOH aqueous solution was added and stirring was continued for 30 minutes. The reaction mixture was left to partition and the organic phase was separated. The organic phase was dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 32.6 g of a colorless liquid product, i.e., 1-[2-(2-hydroxyethoxy)ethyl]piperazine. The yield was 95%.

References

[1] Patent: CN107663183, 2018, A. Location in patent: Paragraph 0022; 0023; 0024

1-Hydroxyethylethoxypiperazine(13349-82-1)Related Product Information

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