4-Isopropoxybenzenesulfonyl chloride Chemical Properties

Melting point:

30-35°C

Boiling point:

112°C 0,01mm

Density 

1.279±0.06 g/cm3(Predicted)

Flash point:

112-113°C/0.01m

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in Toluene

form 

powder to crystal

color 

White to Light yellow to Light orange

Sensitive 

Moisture Sensitive

BRN 

3269058

CAS DataBase Reference

98995-40-5

Safety Information

Risk Statements 

34

Safety Statements 

26-36/37/39-27

RIDADR 

3261

HazardClass 

8

PackingGroup 

II

HS Code 

29162090

MSDS

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4-Isopropoxybenzenesulfonyl chloride Usage And Synthesis

Application

4-Isopropoxybenzenesulfonyl chloride can be used as an organic synthesis intermediate, prepared by reacting isopropoxybenzene with chlorosulfonic acid in the presence of phosphorus pentachloride. It can be used to prepare the compound 5-chloro-3-(2-fluorophenyl)-1-[(4-isopropoxyphenyl)sulfonyl]-6-methoxy-3-[3-(4-methylpiperazin-1-yl)propyl]-1,3-dihydroindole-2-one hydrochloride, which exhibits high affinity and high selectivity for arginine vasopressin (AVP) receptors.

Synthesis

10 g of isopropoxybenzene was cooled to -10??C, 21.84 ml of chlorosulfonic acid was added dropwise, followed by 13.68 g of phosphorus pentachloride and the mixture was stirred at -5??C for 1 hour. The reaction mixture was poured into 250 ml of ice and water and extracted with DCM, the organic phase was dried over Na2SO4 and the solvent was evaporated off in vacuum. The residue was separated by chromatography on silica gel, eluting with a gradient of cyclohexane/AcOEt mixture from (95/5; v/v) to (85/15; v/v) to obtain the expected compound 4-isopropoxybenzenesulfonyl chloride, Mp=93??C.

4-Isopropoxybenzenesulfonyl chloride(98995-40-5)Related Product Information

• PROMETHAZINE
• Ammonium chloride
• Benzyl chloride
• Choline chloride
• Propofol
• 4-Chlorobenzenesulfonyl chloride
• N-Acetylsulfanilyl chloride
• Polyvinyl chloride
• Sodium chloride
• Titanium tetraisopropanolate
• Benzenesulfonyl chloride
• 4-Nitrobenzenesulfonyl chloride
• Calcium chloride
• Mepiquat chloride
• 4-ISOPROPYLBENZENESULFONYL CHLORIDE
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• Methylene Chloride
• 2,2-DIMETHYL-6-CHROMANESULFONYL CHLORIDE