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D(-)-Arginine

Basic information Safety Supplier Related

D(-)-Arginine Basic information

Product Name:
D(-)-Arginine
Synonyms:
  • (2R)-2-ammonio-5-(diaminomethylideneammonio)pentanoate
  • R-(-)-ARGININE
  • (R)-2-AMINO-5-GUANIDINOPENTANOIC ACID
  • RARECHEM AB PP 1748
  • D-ARG
  • D-(-)-ARGININE
  • D-ARGININE
  • D-2-AMINO-5-GUANIDINOVALERIC ACID
CAS:
157-06-2
MF:
C6H14N4O2
MW:
174.2
EINECS:
205-866-5
Product Categories:
  • amino
  • Amino Acids
  • Arginine [Arg, R]
  • Amino Acids and Derivatives
  • alpha-Amino Acids
  • Amino Acids
  • Amino Acids Derivatives
  • chiral
  • PROTECTED AMINO ACID & PEPTIDES
  • Biochemistry
  • for Resolution of Acids
  • Optical Resolution
  • Synthetic Organic Chemistry
Mol File:
157-06-2.mol
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D(-)-Arginine Chemical Properties

Melting point:
226 °C (dec.) (lit.)
alpha 
-28.5 º (c=8, 6 N HCl)
Boiling point:
305.18°C (rough estimate)
Density 
1.2297 (rough estimate)
refractive index 
-23 ° (C=8, 6mol/L HCl)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
2.49±0.24(Predicted)
Water Solubility 
SOLUBLE
Sensitive 
Air Sensitive
BRN 
1725412
InChIKey
ODKSFYDXXFIFQN-SCSAIBSYSA-N
CAS DataBase Reference
157-06-2(CAS DataBase Reference)
EPA Substance Registry System
D-Arginine (157-06-2)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36-36/37/38-20/21/22
Safety Statements 
26-36
WGK Germany 
3
RTECS 
CF1934220
9
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29252000

MSDS

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D(-)-Arginine Usage And Synthesis

Description

D-arginine is the D-form of arginine, which is a kind of amino acids. It can be reacted with hydrogen peroxide for non-enzymatic synthesis of nitric oxide. It has certain pharmacological activities. For example, its derivative, 1-deamino-8-D-arginine vasopressin is useful for the management of haemophilia and von Willebrand’s disease. It also has the potential to inhibit the proliferation of certain cancer cells. In biological research, D-arginine is frequently used in the studies of L-arginine/nitric oxide pathway as an inactive form of L-arginine.

Chemical Properties

white to light yellow crystal powde

Uses

Arginine is an essential amino acid found in food and plant sources, and many biological systems.
D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man.
D-Arginine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. D-Arginine specifically can inhibit arginine decarboxylase enzymes and also functions as a metabolite.

Definition

ChEBI: A D-alpha-amino acid that is the D-isomer of arginine.

References

https://www.alfa.com/zh-cn/catalog/A16137/
Iannucci, N. B., et al. "Antiproliferative effect of 1-deamino-8-D-arginine vasopressin analogs on human breast cancer cells." Future Medicinal Chemistry 3.16(2011):1987-1993.
Ripoll, Giselle, et al. "Angiostatic activity of 1-Deamino-8-D-Arginine vasopressin and novel peptide analogues in breast cancer cells." Cancer Research 68(2008).
Navarro, Eduardo, et al. "Toxicological and Pharmacological Effects of D-Arginine." Basic & Clinical Pharmacology & Toxicology97.3(2005):149-154.

D(-)-Arginine Preparation Products And Raw materials

Raw materials

D(-)-ArginineSupplier

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