2-Amino-6-methyl-5-nitropyridine Chemical Properties

Melting point:

185-189 °C

Boiling point:

276.04°C (rough estimate)

Density 

1.3682 (rough estimate)

refractive index 

1.6500 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.97±0.37(Predicted)

form 

Powder

color 

Yellow

InChIKey

BGMZTBKXOFFTBJ-UHFFFAOYSA-N

CAS DataBase Reference

22280-62-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-20/21/22

Safety Statements 

36/37/39-26-22-36

HazardClass 

6.1

HS Code 

29333999

MSDS

• Language:English Provider:ACROS

2-Amino-6-methyl-5-nitropyridine Usage And Synthesis

Chemical Properties

Light yellow Cryst

Synthesis

General procedure for the synthesis of 2-amino-5-nitro-6-methylpyridine from 2-amino-6-methylpyridine: 10 mL of concentrated sulfuric acid was cooled to 0-1 °C and 2-amino-6-methylpyridine (20 g) was slowly added, keeping the temperature at 0 °C. Subsequently, 110 mL of nitric acid in the ratio of 1:1 by volume was slowly added, stirred at -1 °C and continued stirring at room temperature for 30 min. The reaction mixture was warmed up to 50 °C for 11 hours. After completion of the reaction, the reaction solution was extracted with ethyl acetate (EA). The ethyl acetate layer was washed with ammonia and then the ammonia layer was concentrated. Eventually, the solid product 2-amino-5-nitro-6-methylpyridine (18 g) was precipitated in 75% yield.

References

[1] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0019
[2] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 32-33
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 8, p. 1858 - 1868
[4] Patent: WO2009/30725, 2009, A2. Location in patent: Page/Page column 58
[5] Patent: EP1857444, 2007, A1. Location in patent: Page/Page column 20

2-Amino-6-methyl-5-nitropyridine(22280-62-2)Related Product Information

• 2,6-Lutidine
• Methylparaben
• 4-Dimethylaminopyridine
• Bensulfuron methyl
• Methyl acetate
• 2-Methyl-3-nitropyridine
• Kresoxim-methyl
• 2-Amino-5-methylpyridine
• Methyl propyl carbonate
• Methyl acrylate
• 2-Amino-5-nitropyridine
• 3-Aminopyridine
• METSULFURON METHYL
• 2-Amino-6-methylpyridine
• 2-Aminopyridine
• 2-Bromo-5-nitropyridine
• 4-Methylpyridine
• Thiophanate-methyl