TRANS-ACONITIC ACID Chemical Properties

Melting point:

190 °C (dec.)(lit.)

Boiling point:

225.05°C (rough estimate)

Density 

0.56 g/cm3 (20℃)

refractive index 

1.5860 (estimate)

FEMA 

2010 | ACONITIC ACID

storage temp. 

Store below +30°C.

solubility 

400g/l

pka

2.8(at 25℃)

form 

Solid

color 

White to Off-White

PH

3.14(1 mM solution);2.48(10 mM solution);1.92(100 mM solution)

Odor

at 100.00 %. vegetable musty nut dry toasted

Odor Type

vegetable

Water Solubility 

Soluble in water at 20°C 400g/L. Slightly soluble in ether.

BRN 

1725830

LogP

-0.14

CAS DataBase Reference

4023-65-8(CAS DataBase Reference)

EPA Substance Registry System

1-Propene-1,2,3-tricarboxylic acid, (1E)- (4023-65-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-37/39-36-26

WGK Germany 

3

RTECS 

UD2380000

TSCA 

Yes

HS Code 

2917.19.7050

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

TRANS-ACONITIC ACID Usage And Synthesis

Chemical Properties

WHITE TO OFF-WHITE CRYSTALLINE POWDER

Uses

It plays an important role as an antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes. trans-Aconitic acid is also used in synthesis of aconitate esters. It may be used for cross-linking polyvinyl alcohol film for preparing composite nanofiltration membranes.

Definition

ChEBI: The trans-isomer of aconitic acid.

General Description

trans-Aconitic acid is inhibitor of the tricarboxylic acid cycle and was identified in range grasses.

Biochem/physiol Actions

Antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes.

Purification Methods

Purify trans-acid by dissolving it in AcOH (77g/150mL), filtering and cooling. The acid separates (55g) as colourless needles. A further quantity (10g) can be obtained by reducing the volume of the filtrate. The acid is dried in air then in a vacuum desiccator over NaOH. The acid can be recrystallised from Me2CO/CHCl3. The highest melting point is obtained with the very dry acid. A melting point of 209o was obtained on a Dennis bar [Dennis & Shalton J Am Chem Soc 52 3128 1930, Bruce Org Synth Coll Vol II 12 1943]. [Beilstein 2 IV 2405.]

TRANS-ACONITIC ACID(4023-65-8)Related Product Information

• 2-Ketoglutaric acid
• trans-Cinnamic acid
• Fumaric acid
• TRANS-1,2-DIAMINOCYCLOHEXANE-N,N,N',N'-TETRAACETIC ACID MONOHYDRATE
• trans-Ferulic acid
• 4-METHOXYCINNAMIC ACID
• trans-2-Hexenoic acid
• TRANS-ACONITIC ACID
• TRIETHYL ACONITATE
• TRIALLYL ACONITATE
• TRANS-ACONITIC ACID TRIMETHYL ESTER,trans-Aconitic acid trimethyl
• TRANS-ACONITIC ACID ANHYDRIDE
• trans-Aconitic acid tributyl ester
• (1Z,3Z)-TETRAMETHYL 1-(4-CARBAMOYL-1,2,3-THIADIAZOL-5-YLAMINO)BUTA-1,3-DIENE-1,2,3,4-TETRACARBOXYLATE
• TETRAMETHYL (1Z,3Z)-1-{[4-(ETHOXYCARBONYL)-1,2,3-THIADIAZOL-5-YL]AMINO}BUTA-1,3-DIENE-1,2,3,4-TETRACARBOXYLATE
• 1-Propene-1,2,3-tricarboxylic acid, trihexyl ester
• TRANS-ACONITIC ACID, (1,2,3-PROPENETRICARBOXYLIC ACID)