Acetoin Chemical Properties

Melting point:

15 °C (monomer)

Boiling point:

148 °C(lit.)

Density 

1.013 g/mL at 25 °C(lit.)

vapor pressure 

86hPa at 20℃

FEMA 

2008 | ACETOIN

refractive index 

n20/D 1.417(lit.)

Flash point:

123 °F

storage temp. 

2-8°C

solubility 

All forms are miscible with water, alcohol, Propylene glycol, Glycerine and common flavor materials. Poorly soluble in hydrocarbons.

form 

Liquid (Monomer) or Powder or Crystals (Dimer)

pka

13.21±0.20(Predicted)

color 

Pale yellow to green-yellow or white to yellow

Odor

Intensely creamy-fatty-buttery, penetrating odor, yet milder and less “quinone’’-like than Diacetyl, not as sharp or volatile. Pleasant in extreme dilution.

Odor Type

buttery

Water Solubility 

H2O: 0.1g/mL, clear

Merck 

14,64

JECFA Number

405

BRN 

385636

Stability:

Hygroscopic

InChIKey

ROWKJAVDOGWPAT-UHFFFAOYSA-N

LogP

0.1 at 25℃

CAS DataBase Reference

513-86-0(CAS DataBase Reference)

NIST Chemistry Reference

2-Butanone, 3-hydroxy-(513-86-0)

EPA Substance Registry System

2-Butanone, 3-hydroxy- (513-86-0)

Safety Information

Hazard Codes 

Xi,F

Risk Statements 

10-36/38-38-11

Safety Statements 

26-36-36/37

RIDADR 

UN 2621 3/PG 3

WGK Germany 

1

RTECS 

EL8790000

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29144090

Hazardous Substances Data

513-86-0(Hazardous Substances Data)

Toxicity

skn-rbt 500 mg/24H MOD CNREA8 33,3069,73

MSDS

• Language:English Provider:Acetoin
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Acetoin Usage And Synthesis

Content analysis

It was determined by gas chromatography (GT-10). Use thermal conductivity detector. Use a column of 1.5 m (length), 6.35 mm (inner diameter). The column contains 20% polyethylene glycol 20M (Carbowax 20M) which is loaded on the 60/80 mesh diatomaceous earth carrier. Alternatively we can use other components that can separate diacetyl, water and methylacetyl alcohol. The following conditions were used: the sample was 2 μg; the injection temperature was about 195 ° C; the column temperature was about 130 ° C and the detector was about 230 ° C; the flow rate of the carrier gas was about 35 ml per minute. The average residence time: 2 min 15S for diacetyl, 3 min for water, and 12 mins for methyl acetyl alcohol. The peak area of the resulting methylacetyl alcohol shall not be less than 96.0% of the total area of all peaks.

As a flavor ingredient

Acetoin is a yellowish liquid with a bland, woody, yogurt odor and a fatty creamy “tub” butter taste. It is useful as a flavor ingredient in butter, milk, yogurt or strawberry flavors.

Identification:

Regulatory Status:
CoE: Approved. Bev.: 5 ppm; Food: 50 ppm
FDA: 21 CFR 182.60, 184.1848, 582.60
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (1998).
Reported uses (ppm): (FEMA, 1994) Natural occurrence: Reported found in fresh apple, butter, cheddar cheese, coffee, cocoa, honey, wheat bread and wine.

Chemical Properties

clear yellow solution

Chemical Properties

Acetoin is a yellowish liquid with a bland, woody, yogurt odor and a fatty creamy “tub” butter taste. It is useful as a flavor ingredient in butter, milk, yogurt or strawberry flavors.

Occurrence

Reported found in fresh apple, butter, cheddar cheese, coffee, cocoa, honey, wheat bread and wine

Uses

3-Hydroxy-2-butanone is a chemical used in food flavoring and fragrances. It acts as an intermediate of butanediol cycle in microorganisms. It is used as an aroma carrier in the preparation of flavors and essences.

Uses

Used as pharmaceutical intermediates, food spices; mainly for the preparation of cream, dairy, yogurt and strawberry spices.

Uses

Acetoin is a produced via fermentation of wines, dairy products and sugars by fermentive bacteria. Acetoin is used in food flavoring and fragrances and is also found in some fruits and vegetables.

Definition

ChEBI: A methyl ketone that is butan-2-one substituted by a hydroxy group at position 3.

Aroma threshold values

Aroma characteristics at 1.0%: strong buttery and creamy

Taste threshold values

Taste characteristics at 10 ppm: sweet, creamy, dairy, and butter-like.

General Description

A light-yellow colored liquid. Slightly denser than water. Hence sinks in water. Boiling point 280°F. Flash point between 100 and 141°F. Used to make other chemicals.

Air & Water Reactions

Flammable. Slightly soluble in water.

Reactivity Profile

3-Hydroxy-2-butanone is a ketone and alcohol. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Experimental reproductive effects. LWdly toxic by subcutaneous route. A moderate skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and fumes. See also KETONES

Synthesis

From diacetyl by partial reduction with zinc and acid. It is also a product of fermentation. Acetoin is an optically active compound. The d(–)acetyl methyl carbinol is obtained from fermentation and, in mixture with other products, from the catalytic oxidation of 2,3-butanediol. The 1(+)acetyl methyl carbinol is also obtained from fermentation. The optically pure form has not been isolated; the optically inactive form is prepared synthetically

Purification Methods

Wash acetoin with EtOH until colourless, then with diethyl ether or acetone to remove biacetyl. Dry it in air by suction and dry further in a vacuum desiccator. [Beilstein 1 IV 3991.]

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