Hydroxyacetone Chemical Properties

Melting point:

-17 °C (lit.)

Boiling point:

145-146 °C (lit.)

Density 

1.082 g/mL at 25 °C (lit.)

vapor pressure 

9.01hPa at 25℃

refractive index 

n20/D 1.425(lit.)

FEMA 

4462 | HYDROXYACETONE

Flash point:

133 °F

storage temp. 

2-8°C

solubility 

water: miscible

form 

clear liquid

pka

13.14±0.10(Predicted)

color 

Colorless liquid

Specific Gravity

1.090 (20/4℃)

Odor

at 10.00 % in dipropylene glycol. pungent sweet caramellic ethereal

Odor Type

caramellic

Water Solubility 

Miscible with water, alcohol and ether.

Sensitive 

Hygroscopic

Merck 

14,65

JECFA Number

1945

BRN 

605368

Stability:

Stable. Flammable. Incompatible with strong oxidizing agents, strong acids. Protect from moisture - hygroscopic.

InChIKey

XLSMFKSTNGKWQX-UHFFFAOYSA-N

LogP

0.3 at 25℃

CAS DataBase Reference

116-09-6(CAS DataBase Reference)

NIST Chemistry Reference

2-Propanone, 1-hydroxy-(116-09-6)

EPA Substance Registry System

1-Hydroxyacetone (116-09-6)

Safety Information

Risk Statements 

2017/10/16

Safety Statements 

23-24/25-5

RIDADR 

UN 1224 3/PG 3

WGK Germany 

1

RTECS 

UC2800000

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29144090

Toxicity

mmo-sat 500 mg/plate ABCHA6 47,2461,83

MSDS

• Language:English Provider:Acetol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Hydroxyacetone Usage And Synthesis

Chemical Properties

colourless to yellow liquid

Uses

Hydroxyacetone is a chemical reagent used in various organic chemical reactions. It is a component of the Mannich reaction, amino acid caalyzes direct asymmetric aldol reactions. In the pharmaceutical setting, this compound is used in the synthesis of imidazoles acting as potent and orally active antihypertensive agents. It is also used in the syntheses of 2-oxo-propionaldehyde, imidazoles, polyols, acrolein, dyes and skin tanning agents. It yields (R)-1,2-propanediol upon reduction of hydroxyacetone in the presence of a microbial cell catalyst.

Definition

ChEBI: A propanone that is acetone in which one of the methyl hydrogens is replaced by a hydroxy group.

General Description

Hydroxyacetone (Acetol) is important for the manufacture of polyols, acrolein, dyes and skin tanning agents. It undergoes asymmetric reduction to yield (R)-1,2-propanediol in the presence of microbial cell catalyst.

Safety Profile

Moderately toxic by ingestion. Mutation data reported. An allergen. Implicated in aplastic anemia. A 10 gram dose may be fatal to an adult. skin contact, inhalation, or ingestion can cause asthma, sneezing, irritation of eyes and nose, hives, and eczema. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and fumes.

Synthesis

Hydroxyacetone is produced from Bromoacetone plus sodium formate, followed by Methanol hydrolysis of the formed ester. Or by biochemical synthesis from Propylene glycol with sorbose bacterium.

Hydroxyacetone(116-09-6)Related Product Information

• 3-Hydroxypropionic acid
• Citric acid monohydrate
• 3-Hydroxypropionitrile
• L(+)-Lactic acid
• Hydroxyapatite
• Acetylacetone
• 3'-Hydroxypropiophenone
• Hydroxy silicone oil
• CHLOROPHOSPHONAZO III
• Calcium pyruvate
• Diacetone Alcohol
• RHODIZONIC ACID DIHYDRATE
• Ethyl bromopyruvate
• 2-Hydroxy-1,4-naphoquinone
• Sodium rhodizonate
• 1,3-Dihydroxyacetone
• Phenylacetone
• Propiophenone