3'-Hydroxypropiophenone Chemical Properties

Melting point:

82 °C

Boiling point:

288.9±23.0 °C(Predicted)

Density 

1.104±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Solid

pka

9.09±0.10(Predicted)

color 

Off-White to Beige

CAS DataBase Reference

13103-80-5(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2914500090

3'-Hydroxypropiophenone Usage And Synthesis

Uses

1-?(3-?Hydroxyphenyl)?-?1-?propanone is a reactant used to synthesize tricyclic fused pyridines, a family of alkaloids with antimalarial activity.

Preparation

Preparation by diazotization of m-aminopropiophenone, followed by decomposition of the diazonium salt obtained, (71%)
Also obtained by saponification of 3-acetoxypropiophenone (b.p.2 127–128°) with refluxing 10% sodium hydroxide for 2–3 h (83%)
Also obtained by reductive deamination of 2-amino-5-hydroxypropiophenone (diazotization, followed by decomposition of the diazonium salt formed with copper powder in ethanol)
Also obtained by reaction of ethylmagnesium bromide with 3-hydroxy-N, N-diethylbenzamide in refluxing n-butyl ether for 4 h (75%)
Also obtained by treatment of 3-methoxypropiophenone (b.p.0.05 70–76°) with pyridinium chloride at 210° for 30 min (85%)
Also obtained by treatment of 1-hydroxy-1-(3-hydroxyphenyl)propane (m.p. 105–107°) with DDQ in dioxane for 72 h (97%).

3'-Hydroxypropiophenone(13103-80-5)Related Product Information

• 6,7,4'-Trihydroxyisoflavone
• Shikalkin
• 3',4'-DIHYDROXYPROPIOPHENONE
• 5-Methoxy-3,4-dihydro-2H-naphthalen-1-one
• 6-HYDROXYFLAVANONE
• 2,3-DIHYDRO-9,10-DIHYDROXY-1,4-ANTHRACENEDIONE
• Propiophenone
• 7-Methoxy-1-tetralone
• 6-METHOXYFLAVANONE
• 2',5'-DIHYDROXYPROPIOPHENONE
• PLUMBAGIN
• 5,6-Dimethoxy-1-indanone
• 2-Bromopropiophenone
• 4',6,7-Trimethoxyisoflavone
• Glycitein
• 5-Hydroxy-1-tetralone
• 3′,4′-(Methylenedioxy)propiophenone
• 4-Hydroxyphenylpyruvic acid