3',4'-DIHYDROXYPROPIOPHENONE Chemical Properties

Melting point:

145-146°C

Boiling point:

375.1±27.0 °C(Predicted)

Density 

1.237±0.06 g/cm3(Predicted)

pka

8.75±0.31(Predicted)

CAS DataBase Reference

7451-98-1(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

MSDS

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3',4'-DIHYDROXYPROPIOPHENONE Usage And Synthesis

Uses

It is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Preparation

Obtained by Fries rearrangement of pyrocatechol dipropio-nate with aluminium chloride in chlorobenzene at 80° for 2 h (84%) or in nitrobenzene at 100° for 15 min;
Obtained by Fries rearrangement of pyrocatechol dipropionate with aluminium chloride in the presence of pyrocatechol, in nitrobenzene at 80° for 1 h (37%) or in nitromethane at r.t. for 72 h (76%)
Also obtained by Fries rearrangement of o-methoxyphenyl propionate (1 mol) by aluminium chloride (2 mol) without solvent at 140° for 2 h (51–55%) or in nitrobenzene at 80° for 30–60 min. A demethylation occurs during the reaction.
Also obtained by acylation of pyrocatechol with propionic acid
in the presence of boron trifluoride, at 150° for 2 h in a sealed tube ? (36%)
in the presence of polyphosphoric acid for 15 min in a boiling water bath ? (12%)
Preparation by demethylation of 4-hydroxy-3-methoxypropiophenone with refluxing pyridinium chloride for 10 min (80%)
Also obtained when propiovanillone was heated with an alkali sulfide under conditions used in the kraft cooking process.

3',4'-DIHYDROXYPROPIOPHENONE(7451-98-1)Related Product Information

• 5,6-Dimethoxy-1-indanone
• 2',4',5'-Trihydroxybutyrophenone
• Ethyl 3,4,5-trimethoxybenzoylacetate
• 2-CHLORO-3' 4'-DIMETHOXYBENZIL 97
• 6,7,4'-Trihydroxyisoflavone
• Protopine
• 3′,4′-(Methylenedioxy)propiophenone
• Glycitein
• 3',4'-DIHYDROXYPROPIOPHENONE
• 4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID
• 4',6,7-Trimethoxyisoflavone
• 3,5-Dihydroxypropiophenone
• 2',5'-DIHYDROXYPROPIOPHENONE,2,5-DIHYDROXYPROPIOPHENONE
• 2,4-DIHYDROXYPROPIOPHENONE,2',4'-DIHYDROXYPROPIOPHENONE
• 3,4-Dihydroxyphenylpyruvic acid
• 6,7-DIMETHOXY-2,2-DIMETHYL-4-CHLOROMANONE
• Santalin
• 6,7-DIHYDROXY-4'-METHOXYISOFLAVONE