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2',4'-Dihydroxypropiophenone

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2',4'-Dihydroxypropiophenone Basic information

Product Name:
2',4'-Dihydroxypropiophenone
Synonyms:
  • 2,4-DIHYDROXYPHENYL ETHYL KETONE
  • 2',4'-DIHYDROXYPROPIOPHENONE
  • 2,4-DIHYDROXYPROPIOPHENONE
  • 1-(2,4-DIHYDROXYPHENYL)PROPAN-1-ONE
  • 2',4'-Dihydroxypropiophenone,99%
  • ETHYL 2,4-DIHYDROXYPHENYL KETONE
  • 4-PROPIONYLRESORCINOL
  • LABOTEST-BB LT00261298
CAS:
5792-36-9
MF:
C9H10O3
MW:
166.17
EINECS:
227-329-4
Product Categories:
  • Aromatic Propiophenones (substituted)
  • C9
  • Carbonyl Compounds
  • Ketones
Mol File:
5792-36-9.mol
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2',4'-Dihydroxypropiophenone Chemical Properties

Melting point:
95-98 °C(lit.)
Boiling point:
178 °C / 7mmHg
Density 
1.1708 (rough estimate)
refractive index 
1.5260 (estimate)
pka
8.03±0.40(Predicted)
BRN 
1238635
InChIKey
LLBBBYLDTDJMNU-UHFFFAOYSA-N
CAS DataBase Reference
5792-36-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25
WGK Germany 
3
HS Code 
29145090

MSDS

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2',4'-Dihydroxypropiophenone Usage And Synthesis

Chemical Properties

light yellow crystals or crystalline powder

Preparation

Preparation by reaction of propionic acid with resorcinol,
in the presence of zinc chloride (Nencki reaction), at reflux (160–165°) ? for 15 min, at 150° for 20 min
in the presence of boron trifluoride for 2 h at 70° (79%), at 80° (67%) ? or at 105–108° for 15 min (71%)
in the presence of polyphosphoric acid for 10–20 min in a boiling water bath ? (65%)
in the presence of 70% perchloric acid at reflux for 30 min (70%)
in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid type) ? at 160° for 2–3 h (76%)
Preparation by reaction of propionitrile with resorcinol (Hoesch reaction) (75%) (65%) (46%)(35%)
Preparation by reaction of propionic anhydride with resorcinol
in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid ? type) at 160° for 2–3 h (82%)
in the presence of concentrated sulfuric acid (small drops) at 130° for some ? min (60%)
Also obtained by Fries rearrangement of resorcinol dipropionate
with aluminium chloride at 180–185° for 90 min (25%)
with boron trifluoride, in the presence of resorcinol, at 75° for 1 h (83%)
Also obtained by reaction of ethylmagnesium bromide with 2,4-dihydroxy-N, N-diethylbenzamide in refluxing benzene (12%).

2',4'-Dihydroxypropiophenone Preparation Products And Raw materials

Raw materials

2',4'-DihydroxypropiophenoneSupplier

Shanghai Tombiopharma Chemical Co. Ltd. Gold
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