Suprofen Chemical Properties

Melting point:

278°C

Boiling point:

373.57°C (rough estimate)

Density 

1.2959 (rough estimate)

refractive index 

1.5050 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.5 mg/ml

pka

3.91(at 25℃)

form 

Powder

color 

White to off-white

Water Solubility 

soluble

CAS DataBase Reference

40828-46-4(CAS DataBase Reference)

Safety Information

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2934990002

Toxicity

LD50 (7 days post-drug) in mice, rats, guinea pigs, dogs (mg/kg): 590, 353, 280, 160 orally (Niemegeers)

MSDS

• Language:English Provider:(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate

Suprofen Usage And Synthesis

Description

Suprofen is an arylpropionic acid analgesic/antiinflammatory agent with close structural resemblance to ketoprofen. It is more potent in many assays than indomethacin and ketoprofen and appears better tolerated.

Chemical Properties

Off-White to Light-Brown

Originator

Janssen (Belgium)

Uses

Prostaglandin biosynthesis inhibitor. Analgesic

Uses

Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.

Definition

ChEBI: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.

brand name

Profenal (Alcon);Algiamida;Algiasdi;Bordol;Erdol;Masterfen;Sufenid;Supranol;Surfex;MALDOCIL.

Veterinary Drugs and Treatments

Suprofen is a non-steroidal anti-inflammatory agent similar to flurbiprofen. Suprofen and flurbiprofen are phenylalkanoic acids that inhibit the cyclo-oxygenase enzymes responsible for conversion of arachadonic acid from cell membranes into various prostaglandins. These prostaglandins mediate certain aspects of ocular inflammation including disruption of the blood-aqueous barrier, uveal vasodilation, increases in intraocular pressure, and leakage of white blood cells and protein from uveal vessels into the aqueous humor. Prostaglandins cause iris sphincter constriction (miosis) independent of cholinergic mechanisms. Suprofen can inhibit this intraocular miosis and may also be useful in the management of uveal inflammation (usually in addition to topical steroids).

Suprofen(40828-46-4)Related Product Information

• Flurbiprofen
• (S)-(+)-2-Phenylpropionic acid
• Thifensulfuron
• Propionic acid
• Cephalothin sodium
• Tetrahydrothiophene
• 4-Methoxyphenylacetone
• Suprofen-D3
• LC-R 505
• Cliprofen
• Suprofen
• SUPROFEN USP(CRM STANDARD)
• suprofen acyl glucuronide
• (S)-(+)-Suprofen,(S)-Suprofen
• suprofen-copper(II) complex
• (R)-Suprofen,R(-)-Suprofen
• Dearboxy suprofen
• 4-((5-Bromo-2-thienyl)carbonyl)-alpha-methylbenzeneacetic acid