1-Bromo-3-methyl-2-butanone Chemical Properties

Boiling point:

164 °C

Density 

1.355

refractive index 

1.4685

Flash point:

56 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Chloroform, Ethyl Acetate

form 

Oil

color 

Clear Colourless

Safety Information

HS Code 

2914120000

1-Bromo-3-methyl-2-butanone Usage And Synthesis

Synthesis

Example 1 Synthesis of 1-bromo-3-methylbutan-2-one: (1) Bromine (12.9 mL, 250 mmol) was added slowly and dropwise to an ethanol (EtOH, 250 mL) solution of 3-methyl-2-butanone (25.8 g, 300 mmol) under ice bath cooling conditions. The reaction mixture was stirred continuously for 2 h in an ice bath. After completion of the reaction, it was diluted by adding petroleum ether (600 mL). The organic phase was separated and washed twice with distilled water. The combined aqueous phases were back-extracted twice with petroleum ether. All organic phases were combined and washed twice each with cold sodium carbonate solution and saturated saline in that order. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure at room temperature to afford the target product 1-bromo-3-methylbutan-2-one in 50% yield.

References

[1] Patent: US5910506, 1999, A
[2] Patent: WO2007/14921, 2007, A1. Location in patent: Page/Page column 69
[3] Patent: WO2003/106455, 2003, A1. Location in patent: Page 60
[4] Patent: WO2007/14922, 2007, A1. Location in patent: Page/Page column 79-80
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 8, p. 2922 - 2926

1-Bromo-3-methyl-2-butanone(19967-55-6)Related Product Information

• Bensulfuron methyl
• 3-Methyl-2-butanone
• Kresoxim-methyl
• 4-Bromomethylbenzoic acid
• Methylparaben
• 3,3-Dimethylallyl bromide
• Bromotrimethylsilane
• ISOPROPYL LAURATE
• 4-Methyl-2-pentanone
• Methyl acrylate
• Methyltris(methylethylketoxime)silane
• Isopropyl alcohol
• 2-Butanone oxime
• 2,4-Dimethyl-3-pentanone
• Thiophanate-methyl
• Methyl
• Bromine
• Methyl bromide