ISOBUTYLAMINE HYDROCHLORIDE Chemical Properties

Melting point:

176.0 to 180.0 °C

storage temp. 

Inert atmosphere,Room Temperature

Water Solubility 

almost transparency in Water

form 

powder to crystal

color 

White to Almost white

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

26-36/37/39-39

HS Code 

2921199990

ISOBUTYLAMINE HYDROCHLORIDE Usage And Synthesis

Uses

Isobutylamine hydrochloride is an organic amine hydrochloride, and it has been reported in the literature that it can be used to prepare methyl 3-(2-amino-2-thioethyl)benzoate. Methyl 3-(2-amino-2-thioethyl)benzoate is an important fine chemical raw material and pharmaceutical intermediate. It is a key intermediate for the preparation of a novel phosphate transport inhibitor, 2-[[3-[[4-(2-hydroxyethyl)-2-thiazolyl]methyl]benzoyl]amino]-5-(1-piperidinyl)-,(2E)-2-[[4-chloro-3-(trifluoromethyl)phenyl]methylene]benzoylhydrazine.

Synthesis

The general procedure for the synthesis of isobutylamine hydrochloride from L-valine is as follows: a magnetic stirring bar, 3 mL of n-propanol (n-PrOH), 10 mmol of R-carvone and 5 mmol of L-valine were added to a pressure vessel. The vessel was heated from room temperature to 190 °C in 5 min under stirring conditions. If the reaction mixture was slurry-like, it was continued at 190°C until the solution became clear. After the vessel was cooled below the boiling point of the solvent, it was carefully vented to release the generated CO2. Subsequently, 10 mL of 2M hydrochloric acid (HCl) was added to the vessel and the vessel was again heated to 190 °C in 5 min under stirring and then cooled. The aqueous reaction mixture was washed three times with 25 mL of ether and the aqueous solvent was removed by distillation to give the hydrochloride product. The hydrochloride was transferred to a vacuum oven and dried overnight at 150 °C and 10 Torr pressure. Finally, the hydrochloride product was weighed and analyzed by infrared spectroscopy (IR) and nuclear magnetic resonance (NMR).The NMR data of 2-methylpropan-1-amine hydrochloride were as follows: δH 0.83 (6H, d, J = 4 Hz), 1.79 (1H, m, J = 8 Hz), 2.69 (2H, d, J = 8 Hz); δC 18.8, 26.2, 46.3.

References

[1] Patent: US2014/275569, 2014, A1. Location in patent: Page/Page column 0045; 0048; 0066; 0067

ISOBUTYLAMINE HYDROCHLORIDE(5041-09-8)Related Product Information

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