Ethyl L-valinate hydrochloride Chemical Properties

Melting point:

102-105 °C(lit.)

alpha 

7 º (c=2, H2O)

storage temp. 

Sealed in dry,Room Temperature

Water Solubility 

Soluble in water

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

powder to crystal

color 

White to Almost white

optical activity

[α]20/D +6.7°, c = 2 in H2O

InChI

InChI=1/C7H15NO2.ClH/c1-4-10-7(9)6(8)5(2)3;/h5-6H,4,8H2,1-3H3;1H/t6-;/s3

InChIKey

PQGVTLQEKCJXKF-RGMNGODLSA-N

SMILES

[C@H](N)(C(C)C)C(=O)OCC.Cl |&1:0,r|

CAS DataBase Reference

17609-47-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29224999

MSDS

• Language:English Provider:Ethyl L-valinate hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Ethyl L-valinate hydrochloride Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

The general procedure for the synthesis of L-valine ethyl ester hydrochloride from ethanol and L-valine is as follows: 5 kg (42.7 mol) of L-valine and 4 kg of anhydrous ethanol were added to a 50-liter glass reactor and stirred until complete dissolution. After cooling the reaction mixture to 0-10°C, 8.8 liters of thionyl chloride were added slowly and dropwise. After the dropwise addition was completed, the reaction mixture was gradually heated to reflux and the reaction was maintained for 18 hours. Upon completion of the reaction, the reaction solution was concentrated to dryness. Subsequently, 15 liters of isopropyl acetate was added to the dried residue at 15 to 20°C and stirred for 1 hour. Finally, the product was collected by diafiltration to give 6.1 kg of off-white solid, Intermediate 1 (where R1 is ethyl).

References

[1] Tetrahedron, 2005, vol. 61, # 35, p. 8423 - 8442
[2] Journal of the Indian Chemical Society, 2001, vol. 78, # 3, p. 137 - 141
[3] Journal of the American Chemical Society, 2018, vol. 140, # 22, p. 6818 - 6822
[4] Chemistry of Natural Compounds, 1994, vol. 30, # 2, p. 238 - 244
[5] Khimiya Prirodnykh Soedinenii, 1994, # 2, p. 261 - 268

Ethyl L-valinate hydrochloride(17609-47-1)Related Product Information

• Tris(trimethylsilyl)phosphate
• Triethylamine hydrochloride
• L-Valine methyl ester hydrochloride
• Ethyl pyruvate
• DL-Norvaline
• Ethanol
• Ethyl 3-aminopropanoate hydrochloride
• Ethyl formate
• Topotecan hydrochloride
• Ethyl acrylate
• Valine
• ISOXADIFEN-ETHYL
• Creatine ethyl ester hydrochloride
• Glycine ethyl ester hydrochloride
• D-Glucosamine hydrochloride
• Methoxyammonium chloride
• L-Valine benzyl ester hydrochloride
• L-Valine