L-Glutamic acid alpha-amide Chemical Properties

Melting point:

160 °C

Boiling point:

423.1±40.0 °C(Predicted)

alpha 

D21 +20.5° (c = 6.1 in H2O)

Density 

1.321±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Water (Sparingly)

form 

Solid

pka

pK1 3.81; pK2 7.88(at 25℃)

color 

White to Off-White

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

L-Glutamic acid alpha-amide Usage And Synthesis

Preparation

N-CBZ-γ-benzyl-L-isoglutamine (5 gm.) was dissolved in 100 ml. of 50% ethanol and hydrogenated for 12 hr. at room temperature and atmospheric pressure in the presence of palladium catalyst (5% Pd on calcium carbonate). The catalyst was filtered off and a trace of calcium ions was removed with oxalic acid. The solution was evaporated to dryness, the residue dissolved in a small amount of hot water, and the solution treated with charcoal. Alcohol was added to the cloud point and L-isoglutamine was recovered from the chilled solution as fine white crystals, m.p. 186-188°, yield 65%.

Chemical Properties

White to off-white powder

Definition

ChEBI: L-isoglutamine is an isoglutamine that has L-configuration. It is an isoglutamine and a L-glutamic acid derivative. It is an enantiomer of a D-isoglutamine.

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