Ascrinvacumab
Ascrinvacumab Basic information
- Product Name:
- Ascrinvacumab
- Synonyms:
-
- Ascrinvacumab
- Research Grade Ascrinvacumab (DHE20501)
- PF-03446962
- Research Grade Ascrinvacumab
- CAS:
- 1463459-96-2
- MW:
- 0
- Mol File:
- Mol File
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Ascrinvacumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Ascrinvacumab Usage And Synthesis
Uses
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC)[1].
in vivo
Ascrinvacumab decreases human vessel density and improves antitumor efficacy when combined with bevacizumab (anti-VEGF) in mouse chimera tumor model[1].
References
[1] van Meeteren LA, et al. Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J Biol Chem. 2012 May 25;287(22):18551-61. DOI:10.1074/jbc.M111.338103
AscrinvacumabSupplier
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Guangzhou Hongyuan Chemical Co.,Ltd
- Tel
- 15817493340
- 981810490@qq.com
Wuhan Chemstan Biotechnology Co., Ltd.
- Tel
- 027-65317797 15926423062
- 422450190@qq.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com