Rink Amide Linker Chemical Properties

Melting point:

~180 °C (dec.)

storage temp. 

2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

BRN 

5841553

InChIKey

UPMGJEMWPQOACJ-UHFFFAOYSA-N

SMILES

C(O)(=O)COC1=CC=C(C(C2=CC=C(OC)C=C2OC)NC(OCC2C3C(=CC=CC=3)C3C2=CC=CC=3)=O)C=C1

CAS DataBase Reference

145069-56-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

22-24/25-37/39-26

WGK Germany 

3

HS Code 

29242995

MSDS

• Language:English Provider:SigmaAldrich

Rink Amide Linker Usage And Synthesis

Uses

Rink amide linker (CAS# 145069-56-3) is a selective aldose reductase inhibitor and a potential antidiabetic drug.

Application

Most linkers are bifunctional spacers, with one end permanently anchoring to the resin and the other end temporarily linking to the peptide. Peptides anchoring to Rink linker can be easily cleaved under acidic conditions. Since the discovery of Rink linker, it has been grafted to a variety of resins and widely used for scientific investigations and industrial solid-phase peptide synthesis. Thus, Rink Amide Linker is the key reagent to prepare this series of Rink-resins[1].

Origin

Rink Amide Linker was first designed by Rink and further developed by Bernatowicz and co-workers for the preparation of peptide C-terminal amides[1]. Rink Amide Linker is also known as commercial Knorr linker.

References

[1] Qin L, et al. An improved and practical synthesis of Fmoc Rink linker. Journal of Chemical Research, 2019.

Rink Amide Linker(145069-56-3)Related Product Information

• Fmoc-Phe-OH
• Fmoc-Asp(OtBu)-OH
• Fmoc-Lys(Boc)-OH
• Dimethyldimethoxysilane
• Fomesafen
• RINK AMIDE RESIN
• 4-Dimethylaminopyridine
• N-(9-Fluorenylmethoxycarbonyloxy)succinimide
• 4-Dimethylaminobenzaldehyde
• Dimethoxymethane
• Phenyltriethoxysilane
• Glycine
• 9-Fluorenylmethyl chloroformate
• 6-Aminocaproic acid
• 3,4'-DIAMINODIPHENYLMETHANE
• L-Fmoc-Aspartic acid alpha-tert-butyl ester
• 2-Dimethylaminoethanol
• FMOC-RINK AMIDE-LINKER