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Adenanthin

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Adenanthin Basic information

Product Name:
Adenanthin
Synonyms:
  • Adenanthin
  • Actinodephnine Acuminatin Acuminatoside Adenanthin
  • Kaur-16-ene-6,15-dione,1,7,11-tris(acetyloxy)-3-hydroxy-, (1a,3b,7b,11b)- (9CI)
  • Kaur-16-ene-6,15-dione, 1,7,11-tris(acetyloxy)-3-hydroxy-, (1α,3β,7β,11β)-
CAS:
111917-59-0
MF:
C26H34O9
MW:
490.55
Mol File:
111917-59-0.mol
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Adenanthin Chemical Properties

Boiling point:
593.4±50.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
pka
14.13±0.70(Predicted)
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Adenanthin Usage And Synthesis

Enzyme inhibitor

This diterpenoid (FW = 484.63 g/mol; CAS 111917-59-0) from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. Adenanthin targets the conserved cysteine thiols of peroxiredoxins I and II (or Prx I and Prx II), inhibiting their peroxidase activities and consequently increasing cellular hydrogen peroxide. The latter leads to the activation of Extracellular signal-Regulated Kinases (ERKs) and increased transcription of CCAAT/enhancer-binding protein β (or C/EBPs), further contributing to differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid.

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