3',4'-Difluoroacetophenone Chemical Properties

Melting point:

19-20 °C(lit.)

Boiling point:

94-95 °C13 mm Hg(lit.)

Density 

1.246 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.4916(lit.)

Flash point:

167 °F

storage temp. 

Sealed in dry,Room Temperature

form 

powder to lump to clear liquid

color 

White or Colorless to Light yellow

Specific Gravity

1.246

Water Solubility 

INSOLUBLE

BRN 

2206856

InChIKey

VWJSSJFLXRMYNV-UHFFFAOYSA-N

CAS DataBase Reference

369-33-5(CAS DataBase Reference)

NIST Chemistry Reference

3',4'-Difluoroacetophenone(369-33-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29147000

MSDS

• Language:English Provider:1-(3,4-Difluorophenyl)ethan-1-one
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3',4'-Difluoroacetophenone Usage And Synthesis

Chemical Properties

clear yellowish liquid after melting

Uses

3′,4′-Difluoroacetophenone may be used in chemical synthesis.

Definition

ChEBI: 1-(3,4-Difluorophenyl)ethan-1-one is an aromatic ketone.

Synthesis

Anhydrous aluminum trichloride (117 g) was slowly added to a mixed solution of 1,2-difluorobenzene (50 g) with acetyl chloride (86 g) at room temperature. The formed slurry was heated to 30°C with continuous stirring. Upon completion of the reaction, the red reaction mixture was cooled to 20 °C and subsequently slowly poured into 800 g of ice-water mixture with continued stirring for 30 min. The organic phase was separated and the aqueous phase was extracted with dichloromethane (3 x 500 ml). All organic phases were combined and washed sequentially with water (2 x 500 ml), saturated sodium bicarbonate solution (2 x 500 ml) and 15% brine (2 x 500 ml), followed by drying with anhydrous sodium sulfate. The organic phases were concentrated to remove the solvent and finally distilled under reduced pressure to collect the fractions at 95 °C/13 mmHg to give 3',4'-difluoroacetophenone (51 g).

References

[1] Journal of Fluorine Chemistry, 1980, vol. 15, p. 245 - 252
[2] Journal of the Indian Chemical Society, 1982, vol. 59, # 2, p. 293 - 294
[3] Heterocycles, 1981, vol. 16, # 9, p. 1545 - 1553
[4] Journal of Medicinal Chemistry, 1979, vol. 22, # 11, p. 1385 - 1389
[5] Heterocycles, 1981, vol. 16, # 1, p. 71 - 76

3',4'-Difluoroacetophenone (369-33-5)Related Product Information

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