magnolin
magnolin Basic information
- Product Name:
- magnolin
- Synonyms:
-
- 1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)
- Medioresinol dimethyl ether
- tetrahydro-4-(3,4,5-trimethoxyphenyl)-,(1S,3aR,4S,6aR)-
- Magnolin
- Maglin
- Magnolin, 98%, from Magnolia liliflora Desr.
- (1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan
- 1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1S,3aR,4S,6aR)-
- CAS:
- 31008-18-1
- MF:
- C23H28O7
- MW:
- 416.46
- Product Categories:
-
- Miscellaneous Natural Products
- Mol File:
- 31008-18-1.mol
magnolin Chemical Properties
- Melting point:
- 91.4-92.9 °C
- Boiling point:
- 536.9±50.0 °C(Predicted)
- Density
- 1.178±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- color
- White to Off-White
Safety Information
- Safety Statements
- 24/25
- HS Code
- 29329990
magnolin Usage And Synthesis
Description
Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.
Uses
Magnolin is a lignan extract from Magnoliae Flos, displaying anti-asthma and anti-inflammatory activity.
in vitro
Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration.
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