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ARTEMISININ

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ARTEMISININ Basic information

Product Name:
ARTEMISININ
Synonyms:
  • 4’-methylkaempferol
  • 3,5,7-trihydroxy-2-(4-methoxyphenyl)-1-benzopyran-4-one
  • Kaempferide~3,5,7-Trihydroxy-4-methoxyflavone
  • 3,5,7-trihydroxy-2-(4-methoxyphenyl)-4-benzopyrone
  • Kaemperide
  • 3,5,7-Trihydroxy-2-(4-methoxy-phenyl)-chromen-4-
  • KAEMPFERIDE
  • ARTEMISIA ANNUA
CAS:
491-54-3
MF:
C16H12O6
MW:
300.26
EINECS:
207-738-4
Product Categories:
  • Flavanols
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
491-54-3.mol
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ARTEMISININ Chemical Properties

Melting point:
156-157 °C(lit.)
Boiling point:
543.8±50.0 °C(Predicted)
Density 
1.538
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
pka
6.32±0.40(Predicted)
form 
Solid
color 
Yellow
BRN 
305378
LogP
2.740 (est)
CAS DataBase Reference
491-54-3
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Safety Information

Safety Statements 
24/25
WGK Germany 
2
RTECS 
KD4170000
HS Code 
29329990

MSDS

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ARTEMISININ Usage And Synthesis

Chemical Properties

Yellow powder

Uses

Kaempferide is a flavonoid that maintains anti-radical and anti-oxidant capabilities, as well as anti-tumour possibilities. Impurity of Icaritin (I163700).

Definition

ChEBI: A monomethoxyflavone that is the 4'-O-methyl derivative of kaempferol.

Biological Activity

the effects of phytoestrogens have been studied in the hypothalamic-pituitary-gonadal axis and various non-gonadal targets. epidemiologic and experimental evidence indicates a protective effect of phytoestrogens also in colorectal cancer. the mechanism through which estrogenic molecules control colorectal cancer tumorigenesis could possibly involve estrogen receptor β, which is the predominantly expressed estrogen receptor subtype in colon mucosa.

in vitro

kaempferide triglycoside proved to inhibit the proliferation of native and estrogen receptor β overexpressing colon cancer cells via a mechanism not mediated by ligand binding dependent estrogen receptor activation. it affected hct8 cell cycle progression through increasing the g0/g1 cell fraction and in estrogen receptor β overexpressing cells increased two antioxidant enzymes [1].

in vivo

the aim of one previous study was to evaluate the effect of kaempferol on tissue lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal cancer in male wistar rats and to compare its efficacy with irinotecan. this study revealed that kaempferol could be safely used as a chemopreventive agent in colorectal cancer [2].

References

[1] martineti v, tognarini i, azzari c, carbonell sala s, clematis f, dolci m, lanzotti v, tonelli f, brandi ml, curir p. inhibition of in vitro growth and arrest in the g0/g1 phase of hct8 line human colon cancer cells by kaempferide triglycoside from dianthus caryophyllus. phytother res. 2010 sep;24(9):1302-8.
[2] nirmala p, ramanathan m. effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats. eur j pharmacol. 2011 mar 1;654(1):75-9.

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