TAMARIXETIN Chemical Properties

Melting point:

265-268°C

Boiling point:

601.8±55.0 °C(Predicted)

Density 

1.634±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: Slightly Soluble; Methanol: Slightly Soluble

form 

A solid

pka

6.31±0.40(Predicted)

LogP

2.420 (est)

Safety Information

Risk Statements 

22

Safety Statements 

22-45

TAMARIXETIN Usage And Synthesis

Description

4''-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4''-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC₅₀ values ranging from 5.5-24.1 μM. It induces G₂-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4''-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC₅₀ = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4''-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC₅₀ = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).

Uses

A major metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Definition

ChEBI: A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

TAMARIXETIN(603-61-2)Related Product Information

• SPIRAEOSIDE
• ARTEMETIN
• 3,7,3',4'-TETRAMETHYLGOSSYPETIN
• TAMARIXETIN
• QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER
• CASTICIN
• 3,5,7-TRIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE
• 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE
• QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER
• Fisetin
• 4'-METHOXYFLAVONE
• QUERCETIN-7,4'-DIGLUCOSIDE
• 4',7-DIMETHOXY-3,3',5-TRIHYDROXYFLAVONE
• Tamarixetin 3-methylether
• 3,3',4',5,6,7,8-heptamethoxyflavone
• 3'-BENZYLOXY-5,7-DIHYDROXY-3,4'-DIMETHOXYFLAVONE
• QUERCETINPENTAACETATE
• Ombuoside