kaempferol 3-O-sophoroside
kaempferol 3-O-sophoroside Basic information
- Product Name:
- kaempferol 3-O-sophoroside
- Synonyms:
-
- kaempferol 3-O-sophoroside
- 3-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyloxy)-4',5,7-trihydroxyflavone
- 3-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-4',5,7-trihydroxyflavone
- 3-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-4',5,7-trihydroxyflavone
- Kaempferol 3-sophoroside
- Kaempferol 3-β-sophoroside
- Sophoraflavanoloside
- 3-[(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
- CAS:
- 19895-95-5
- MF:
- C27H30O16
- MW:
- 610.52
- Mol File:
- 19895-95-5.mol
kaempferol 3-O-sophoroside Chemical Properties
- Melting point:
- 194-198℃
- Boiling point:
- 995.0±65.0 °C(Predicted)
- Density
- 1.82
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- 6.20±0.40(Predicted)
- form
- Solid
- color
- Light Yellow
kaempferol 3-O-sophoroside Usage And Synthesis
Uses
Kaempferol 3-β-Sophoroside is a derivative of Kaempferol (K100000), a plant flavonoid which play a beneficial role in human health promotion.
Definition
ChEBI: A kaempferol O-glucoside that is kaempferol attached to a beta-D-sophorosyl residue at position 3 via a glycosidic linkage.
in vivo
Kaempferol 3-O-sophoroside (10 and 20 mg/kg, p.o., once daily for 20 days) binds to AMP-activated protein kinase (AMPK) to promote brain-derived neurotrophic factor (BDNF) production and autophagy enhancement in corticosterone (HY-B1618)-induced mouse depression model and chronic unpredictable mild stress (CUMS) model, ultimately achieving antidepressant effects[3]. Kaempferol 3-O-sophoroside (100 and 200 mg/kg, p.o., 30-minute administration duration) exhibits analgesic effects in the acetic acid-induced writhing mice model[4].
| Animal Model: | Acetic acid-induced writhing mice model[4] |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | Oral gavage (p.o.), administration duration of 30 minutes |
| Result: | Caused dose-dependent inhibition of the writhing response induced by acetic acid. |
| Animal Model: | Corticosterone (HY-B1618)-induced mouse depression model; Chronic unpredictable mild stress (CUMS) model[3] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | Oral gavage (p.o.), once per day for 20 consecutive days |
| Result: | Ameliorated weight loss, dyskinesia, and hippocampal volume reduction induced by Corticosterone and CUMS. |
IC 50
TLR2; TLR4
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kaempferol 3-O-sophoroside(19895-95-5)Related Product Information
- GARDENIN B
- 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one
- KAEMPFEROL-3-O-RUTINOSIDE
- KaeMpferol-4'-O-β-D-glucopyranoside
- Kaempferol
- KAEMPFEROL-7-O-GLUCOSIDE
- Quercetin-7-O-β-D-glucopyranoside
- Sophoricoside
- hydroxygenkwanin
- Rutin
- MEDICAGOL
- KAEMPFEROL-3-GLUCURONIDE
- Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers)
- ARTEMISININ
- Kaempferol 3-neohesperidoside
- Kaempferol 3-(6-O-glucopyranosylglucoside)
- Kaempferol 3-sophoroside-7-glucoside
- KaeMpferol 3-sophoroside-7-rhaMnoside