NG-MONOMETHYL-L-ARGININE ACETATE Chemical Properties

Melting point:

180-190 °C

alpha 

D22 +9.5° (c = 0.10 in water)

Boiling point:

391.35°C (rough estimate)

Density 

1.2162 (rough estimate)

refractive index 

1.6300 (estimate)

storage temp. 

2-8°C

solubility 

H₂O: 1 mg/mL, clear, colorless

form 

Powder

color 

White to Off-white

Water Solubility 

Soluble in water (50 mM)

BRN 

6674255

Stability:

Store at - 5°C; Desiccate Recommended

InChIKey

IKPNWIGTWUZCKM-JEDNCBNOSA-N

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29252900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

NG-MONOMETHYL-L-ARGININE ACETATE Usage And Synthesis

Description

L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared. It is a relatively non-selective inhibitor of all NOS isoforms. The K_i values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.

Chemical Properties

White Crystalline Powder

Uses

A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells

Uses

Reagent to inhibit nitric oxide production in biological systems.

Uses

Nitric oxide synthase inhibitor

Biological Activity

Competitive, irreversible inhibitor of all three NOS isoforms.

Biochem/physiol Actions

NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

storage

Room temperature

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