L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Chemical Properties

storage temp. 

-20°C

solubility 

DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml

form 

White to off-white solid.

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26-36

WGK Germany 

3

MSDS

• Language:English Provider:ACROS

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Usage And Synthesis

Description

L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC₅₀ values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.

Uses

L-N⁶-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:

• to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
• to study its effects on leptin-induced inflammation in hepatocytes
• to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)

Definition

ChEBI: N(6)-acetimidoyl-L-lysine dihydrochloride is a hydrochloride salt prepared from N(6)-acetimidoyl-L-lysine and two equivalents of hydrogen chloride. A selective inhibitor of inducible nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It contains a N(6)-acetimidoyl-L-lysinium(2+).

Biochem/physiol Actions

Selective inhibitor of inducible nitric oxide synthase (iNOS).

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