AMINOGUANIDINE HEMISULFATE Chemical Properties

Melting point:

200 °C

Density 

1.36 g/cm3 (20℃)

storage temp. 

Store below +30°C.

solubility 

170g/l

form 

White solid.

color 

White to Almost white

PH

4-6 (25g/l, H2O, 20℃)

Water Solubility 

almost transparency

CAS DataBase Reference

996-19-0(CAS DataBase Reference)

EPA Substance Registry System

Hydrazinecarboximidamide, sulfate (2:1) (996-19-0)

Safety Information

Safety Statements 

24/25

WGK Germany 

2

HS Code 

29280000

Toxicity

LD50 orally in Rabbit: > 2000 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

AMINOGUANIDINE HEMISULFATE Usage And Synthesis

Chemical Properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

Uses

NO synthase inhibitor

Uses

Aminoguanidine inhibits both constitutive and inducible nitric oxide synthetase. Aminoguanidine has also been used to study the effects of nitric oxide on ovulation and ovarian steroidogenesis and prostaglandin production.

Application

Aminoguanidine hemisulfate is used in the treatment of patients with chronic granulomatous disease, which is a form of leukemia. This drug also has been shown to inhibit follicular growth and nitrogen atoms, as well as to inhibit the production of protein-bound polyamines. It was found to have no effect on the intracellular calcium concentration or on growth factor release by receptor cells. It has been shown that it can inhibit cyclase activity and therefore reduce proliferation of cells in experimental models. The ester hydrochloride salt of this compound is an inhibitor of guanylate cyclase, which prevents the conversion of guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP).

Biochem/physiol Actions

Inhibits both constitutive and inducible nitric oxide synthetase

AMINOGUANIDINE HEMISULFATE(996-19-0)Related Product Information

• NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
• L-N5-(1-IMINOETHYL)ORNITHINE*HYDROCHLORI DE
• LUCIGENIN
• Aminoguanidine bicarbonate
• NG-MONOMETHYL-L-ARGININE ACETATE
• IroMycin A
• Benzyl carbamate
• 2-IMINOBIOTIN HYDROBROMIDE
• N'-Nitro-L-arginine-methyl ester hydrochloride
• Sulfamic acid
• L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
• L-THIOCITRULLINE DIHYDROCHLORIDE
• L-NAA HCL
• 7-NINA
• Methylhydrazine sulfate
• pimagedine
• Hydrazine sulfate
• Aminoguanidinium sulphate