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Olivetol

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Olivetol Basic information

Product Name:
Olivetol
Synonyms:
  • 5-PENTYLRESORCINOL
  • 5-PENTYL 1,3-BENZENEDIOL
  • 5-N-PENTYLRESORCINOL
  • 5-AMYL RESORCINOL
  • 3,5-dihydroxyamylbenzene
  • AURORA KA-7378
  • OLIVETOL
  • Olivetol(3,5-hydroxypentylbenzene)
CAS:
500-66-3
MF:
C11H16O2
MW:
180.24
EINECS:
207-908-8
Product Categories:
  • API intermediates
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 500-66-3
Mol File:
500-66-3.mol
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Olivetol Chemical Properties

Melting point:
46-48 °C(lit.)
Boiling point:
164 °C
Density 
1.068±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
9.59±0.10(Predicted)
color 
Colourless to Beige
Stability:
Light Sensitive
InChI
InChI=1S/C11H16O2/c1-2-3-4-5-9-6-10(12)8-11(13)7-9/h6-8,12-13H,2-5H2,1H3
InChIKey
IRMPFYJSHJGOPE-UHFFFAOYSA-N
SMILES
C1(O)=CC(CCCCC)=CC(O)=C1
CAS DataBase Reference
500-66-3(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Benzenediol, 5-pentyl-(500-66-3)
EPA Substance Registry System
Olivetol (500-66-3)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/39
WGK Germany 
3
RTECS 
VH2880000
HS Code 
2907290090

MSDS

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Olivetol Usage And Synthesis

Chemical Properties

Olivetol is an off-white crystals or olive to light purple waxy solid. Forms monohydrate (melting point: 102-106°F). Olivetol is a member of the class of resorcinols that is resorcinol in which the hydrogen at position 5 is replaced by a pentyl group. It has a role as a lichen metabolite.

Physical properties

light purple to brown crystalline mass.

Uses

Olivetol was used as a template molecule in the synthesis of molecularly imprinted polymer (MIP). It was also used as an inhibitor of (S)-mephenytoin 4'-hydroxylase activity of recombinant CYP2C19.

Application

Olivetol is a precursor in various syntheses of tetrahydrocannabinol.

Preparation

olivetol can also be formed through hydrolysis of intermediate polyketide CoAs or spontaneous cyclization.

Definition

ChEBI: Olivetol is a member of the class of resorcinols that is resorcinol in which the hydrogen at position 5 is replaced by a pentyl group. It has a role as a lichen metabolite.

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 3456, 1977 DOI: 10.1021/jo00441a036

General Description

Olivetol appears as off-white crystals or olive to light purple waxy solid. Forms monohydrate (melting point: 102-106°F). (NTP, 1992)

Air & Water Reactions

Sensitive to air. Insoluble in water.

Reactivity Profile

Olivetol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.

Fire Hazard

Olivetol is probably combustible.

Biological Activity

Olivetol (5-Pentylresorcinol, 5-n-Amylresorcinol) is a naturally occurring organic compound being a precursor in various syntheses of tetrahydrocannabinol. It acts as a competitive inhibitor of the cannabinoid receptors CB1 and CB2.

Safety

Olivetol is still a very new product. It has not been researched nearly enough to prove it's safe to use. So far, no one has reported any adverse side effects as far as we know. Until more information is available, carefully control your THC intake instead of relying on an untested gelcap.

Mode of action

When you look at olivetol's molecular structure, it'll look very familiar. It's as if someone took a THC molecule and sliced it in two. Olivetol, like THC, works by binding with the CB1 receptors that exist all over your body and brain. But, olivetol is thought to be smaller and stickier than THC, so that helps it reduce a raging high in two ways. First, it slips into any open receptors before THC can get there to block them—so you won't get any higher. Second, it bumps into THC molecules that are already lodged in a CB1 receptor to knock them loose and take their place. That's how it brings you down.
According to numerous personal accounts, olivetol works, but we don't know exactly how it does so. More research and investigation is needed, but in theory it's very similar to how Narcan acts to reverse opiate overdoses.

OlivetolSupplier

Xiamen Work-For-World Medcine Co., Ltd Gold
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0086-512-66702819 13382131678
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Jinan Cen Ben Medical Technology Co., Ltd Gold
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0531-0531-69959492 14793566
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info@cenpharm.com
Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd Gold
Tel
13732973797
Email
liu@zybiopharma.com