2'-Deoxyguanosine Chemical Properties

Melting point:

300 °C

Boiling point:

410.43°C (rough estimate)

Density 

1.3382 (rough estimate)

refractive index 

-42 ° (C=0.2, 1mol/L NaOH)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

NH₄OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown

form 

powder

pka

9?+-.0.20(Predicted)

color 

White to Off-white

PH

2.37；9.33

Water Solubility 

Slightly soluble in water.

λmax

255 (pH 1)

BRN 

39814

InChIKey

OROIAVZITJBGSM-OJFKHTATSA-N

CAS DataBase Reference

961-07-9(CAS DataBase Reference)

NIST Chemistry Reference

Deoxyguanosine(961-07-9)

EPA Substance Registry System

Guanosine, 2'-deoxy- (961-07-9)

Safety Information

Risk Statements 

20/21/22

Safety Statements 

24/25

WGK Germany 

3

RTECS 

MF8760000

F 

10-23

TSCA 

Yes

HS Code 

29349990

MSDS

• Language:English Provider:2'-Deoxyguanosine monohydrate
• Language:English Provider:SigmaAldrich

2'-Deoxyguanosine Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

2'-Deoxyguanosine (Deoxyguanosine; dG) is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Definition

ChEBI: 2'-deoxyguanosine is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.

Purification Methods

2'-Deoxyguanosine recrystallises from H2O as the monohydrate. [Brown &C5440 Lythgoe J Chem Soc 1990 1950, L

2'-Deoxyguanosine(961-07-9)Related Product Information

• Guanosine
• Guanine
• Acyclovir
• Chloral hydrate
• Guanosine 5'-monophosphate disodium salt
• 5'-Guanylic acid
• Deoxycholic acid
• MELIBIOSE
• Guanylic acid sodium salt
• DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS*
• 2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA),2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA)
• 2’-deoxyguanosine5’-phosphat
• 2’-deoxyguanosine5’-(tetrahydrogentriphosphate
• N2-ISOBUTYRYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE,N2-ISOBUTYRYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE
• hydrazine hydrate
• [5',5''-2H2]2'-DEOXYGUANOSINE MONOHYDRATE
• 3'-deoxyguanosine monohydrate
• hydrate