Basic information Safety Supplier Related

JNJ 31020028

Basic information Safety Supplier Related

JNJ 31020028 Basic information

Product Name:
JNJ 31020028
Synonyms:
  • JNJ 31020028
  • N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide
  • N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide
  • 4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE
  • JNJ31020028, >98%
  • JNJ-31020028?, >98%
  • CS-1745
  • JNJ-31020028;JNJ 31020028
CAS:
1094873-14-9
MF:
C34H36FN5O2
MW:
565.68
Product Categories:
  • Inhibitors
Mol File:
1094873-14-9.mol
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JNJ 31020028 Chemical Properties

Boiling point:
677.5±55.0 °C(Predicted)
Density 
1.228±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 21.5 mg/mL (38.01 mM; Need ultrasonic and warming)
form 
Powder
pka
12.14±0.70(Predicted)
color 
Light yellow to yellow
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JNJ 31020028 Usage And Synthesis

Description

JNJ-31020028 is a brain-permeable selective antagonist of the neuropeptide Y (NPY) receptor Y2 (IC50s = 8.51, 6.03, and 6.17 nM for human, rat, and mouse receptors, respectively) with over 100-fold selectivity for Y2 over Y1, Y4, and Y5 receptors. JNJ-31020028 inhibits calcium release induced by peptide YY in a functional assay in KAN-TS cells (pKB = 8.04) and blocks NPY(13-36)-induced decreases in twitch contraction amplitude in isolated rat vas deferens (IC50 = 7.94 nM). Administration of JNJ-31020028 to rats during abstinence (20 mg/kg per day, i.p.) reverses nicotine-induced social anxiety-like behavior and increases hippocampal Y2 receptor mRNA levels. It reverses withdrawal-induced anxiety-like behavior in rats in the elevated plus maze following a single bolus dose of alcohol when administered at a dose of 15 mg/kg. In an olfactory bulbectomized rat model of depression, chronic JNJ-31020028 treatment (10 nmol per day, i.c.v.) decreases immobility time in the forced swim test but has no effect in control animals.

Uses

JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease[1].

in vivo

JNJ-31020028 (0-20 mg/kg; s.c. once) affects the level of plasma corticosterone and refeeding result in stressed animals[1].

Animal Model:Stressed and nonstressed male Sprague-Dawley rats[1]
Dosage:0, 3, 10 and 20 mg/kg
Administration:Subcutaneous injection; 0-20 mg/kg once
Result:Significantly decreased plasma corticosterone levels in stressed animals, but not significantly affected plasma corticosterone levels in nonstressed animals. Attenuated effects of stress on refeeding.

References

[1] Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y DOI:10.1007/s00213-009-1726-x

JNJ 31020028Supplier

Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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info@chemexpress.com
MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
AdooQ BioScience, LLC
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+1 (866) 930-6790
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
Email
info@adooq.cn
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JNJ 31020028(1094873-14-9)Related Product Information