trans/cis Resveratrol-D4 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: >100 mg/ml,DMSO: >50mg/ml,Ethanol: >50mg/ml,PBS (pH 7.2): <100 μg/ml

trans/cis Resveratrol-D4 Usage And Synthesis

Description

trans-Resveratrol-d₄ is intended for use as an internal standard for the quantification of trans-resveratrol by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC₅₀s = 15 and 3.7 μM, respectively), but not COX-2 (EC₅₀s = >100 μM and 85 μM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; ; EC₅₀ = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC₅₀s = 37, 50, 20, <10, 25, 3.3, and 5 μM, respectively) in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.

Uses

Resveratrol-d4 is labelled Resveratrol (R150000) which is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.

trans/cis Resveratrol-D4(1089051-56-8)Related Product Information

• CIS-TRIMETHOXY STILBENE
• Dihydroresveratrol
• trans Resveratrol 3-O-β-D-Glucuronide
• trans Resveratrol 4O-b-D-Glucuronide
• cis Resveratrol
• Azo-Resveratrol
• Oxyresveratrol
• 4'-Methoxyresveratrol
• Resveratrol
• Resveratrol-13C6
• 3,5-DIHYDROXY-4'-METHOXYSTILBENE 3-O-BETA-D-GLUCOSIDE
• 3,4',5-TRIMETHOXY-TRANS-STILBENE
• PICEATANNOL
• 3,5-DIHYDROXY-4'-BROMOSTILBENE
• Acetyl-trans-resveratrol
• trans Resveratrol 3-Sulfate
• cis Resveratrol 3-O-b-D-Glucuronide
• 1-O-Levulinoyl Resveratrol Diacetate