3-Bromo-7-azaindole
3-Bromo-7-azaindole Basic information
- Product Name:
- 3-Bromo-7-azaindole
- Synonyms:
-
- 3-BROMO-7-AZAINDOLE
- 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
- 1H-PYRROLO[2,3-B]PYRIDINE, 3-BROMO-
- 3-Bromo-7-azaindole (3-bromo-1H-pyrrolo[2,3-b]pyridine）
- 3-broMo-1H-pyrrolo[2,3-b]pyridine 5-(trifluoroMethyl)-1H-iMidazole
- 3-BroMo-pyrrolo[2,3-b]pyridine
- 3-Bromo-7-azaindole 97%
- 1,2,3,4,5-Cyclopentanepentayl,1-[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2-[(R)-(dimethylamino)phenylmethyl]-,ironsalt(2:5)
- CAS:
- 74420-15-8
- MF:
- C7H5BrN2
- MW:
- 197.03
- Product Categories:
-
- Azaindoles
- Halides
- CHIRAL CHEMICALS
- Fused Ring Systems
- Azaindole
- Building Blocks
- Indole Derivatives
- Miscellaneous Reagents
- Heterocycles
- Mol File:
- 74420-15-8.mol
3-Bromo-7-azaindole Chemical Properties
- Melting point:
- 185-189 °C
- Boiling point:
- 345.4±42.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Dichloromethane, Ethyl Acetate
- pka
- 5.89±0.20(Predicted)
- form
- Powder
- color
- White to brown
- CAS DataBase Reference
- 74420-15-8(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-36/37/39
- RIDADR
- UN 2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29339900
3-Bromo-7-azaindole Usage And Synthesis
Chemical Properties
3-Bromo-7-azaindole is Yellow solid
Uses
3-Bromo-7-azaindole is a reagent used in the preparation of biologically active Azaindoles.
Uses
Useful starter in 7-azaindole chemistry
Synthesis
271-63-6
74420-15-8
General procedure for the synthesis of 3-bromo-1H-pyrrolo[2,3-b]pyridine from 7-azaindole: 100 mmol of 7-azaindole was dissolved in an appropriate amount of organic solvent and transferred to the reactor. Subsequently, 40 mmol of catalyst consisting of nickel(II) acetate mixed with triethanolamine borosilicate in a 3:1 ratio was added. The temperature of the reaction system was adjusted to 100 °C and the stirring speed was maintained at 90 rpm. The reaction was carried out by slowly passing 300 mmol of bromine gas and refluxed for 3 hours. After completion of the reaction, the target product 3-bromo-7-azaindole was obtained in 99.0% yield after purification.
References
[1] Patent: CN106349242, 2017, A. Location in patent: Paragraph 0033; 0034; 0035; 0036; 0037; 0038
[2] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 701 - 719
[3] Patent: WO2013/6634, 2013, A2. Location in patent: Paragraph 0379-0382
[4] Patent: WO2013/70606, 2013, A1. Location in patent: Paragraph 00383-00385
[5] Patent: WO2014/74471, 2014, A1. Location in patent: Paragraph 0268-0270
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3-Bromo-7-azaindole(74420-15-8)Related Product Information
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- Polyvinylpyrrolidone
- 7-Azaindole
- 3-Bromoanisole
- Pyrrolidine
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- TERT-BUTYL 3-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE
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- 3-BROMO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE