(R)-(-)-1-METHOXY-2-PROPANOL Chemical Properties

Melting point:

-97 °C

Boiling point:

119-121 °C (lit.)

Density 

0.921 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.403

Flash point:

33 °C

storage temp. 

Sealed in dry,2-8°C

form 

Liquid

pka

14.49±0.20(Predicted)

color 

Clear colorless

optical activity

[α]20/D 22±2°, c = 10% in chloroform

BRN 

1718941

InChIKey

ARXJGSRGQADJSQ-SCSAIBSYSA-N

CAS DataBase Reference

4984-22-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

F,Xn

Risk Statements 

10-15

Safety Statements 

24-43-7/8

RIDADR 

UN 3092 3/PG 3

WGK Germany 

1

HazardClass 

3

PackingGroup 

Ⅲ

HS Code 

29051990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

(R)-(-)-1-METHOXY-2-PROPANOL Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(-)-1-Methoxy-2-propanol can be used as a reactant to prepare:

• (S)-3-(ethoxycarbonyl)-5-((1-methoxypropan-2-yl)oxy)benzoic acid, a key intermediate to synthesize phenylethyl benzamide derivatives, which can be used as glucokinase activators.
• Chiral pyrazolopyrimidinone derivatives as potential phosphodiesterase enzyme (PDE5) inhibitors.
• Aryl or alkyl ethers via etherification reaction.

General Description

(R)-(-)-1-Methoxy-2-propanol is a chiral secondary alcohol. It is formed during the hydrolysis of (R)-1-methoxy-2-propyl-acetate in the presence of Candida antarctica lipase B.

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