7-Deaza-ddG
7-Deaza-ddG Basic information
- Product Name:
- 7-Deaza-ddG
- Synonyms:
-
- 7-Deaza-ddG
- 2',3'-Dideoxy-7-Deazaguanosine
- 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-1,7-dihydro-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]- (9CI)
- 2-Amino-7-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
- 2-Amino-7-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
- CAS:
- 111869-49-9
- MF:
- C11H14N4O3
- MW:
- 250.25
- Mol File:
- 111869-49-9.mol
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7-Deaza-ddG Chemical Properties
- Melting point:
- 228 °C (decomp)
- Density
- 1.75±0.1 g/cm3(Predicted)
- pka
- 11.29±0.20(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C11H14N4O3/c12-11-13-9-7(10(17)14-11)3-4-15(9)8-2-1-6(5-16)18-8/h3-4,6,8,16H,1-2,5H2,(H3,12,13,14,17)/t6-,8+/m0/s1
- InChIKey
- IRKZBFORRGBSAO-POYBYMJQSA-N
- SMILES
- C1(N)=NC(=O)C2C=CN([C@H]3CC[C@@H](CO)O3)C=2N1
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7-Deaza-ddG Usage And Synthesis
Uses
7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM[1].
IC 50
HIV-1
References
[1] Nicholas A Boyle, et al. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem. 2005 Apr 7;48(7):2695-700. DOI:10.1021/jm040101y
7-Deaza-ddGSupplier
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