A-SPINASTEROL Chemical Properties

Melting point:

168-169°

alpha 

D25 -3.6° (c = 2.8 in chloroform)

Boiling point:

500.0±44.0 °C(Predicted)

Density 

0.98±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)

form 

Solid

pka

15.10±0.70(Predicted)

color 

White to Off-White

biological source

Aster scaber

Stability:

Light Sensitive

A-SPINASTEROL Usage And Synthesis

Uses

α-Spinasterol was identified as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties.

Definition

ChEBI: Alpha-Spinasterol is a steroid. It derives from a hydride of a stigmastane.

Biological Activity

α-Spinasterol is a blood-brain barrier-permeable and orally active plant phytosterol with antioxidant, anticonvulsant (0.1-1 mg/kg i.p. in mice), antidepressant (1-2 mg/kg i.p. in mice) and anti-inflammatory (0.001-1 mg/kg, i.p. or 1-10 mg/kg, i.g. in mice) properties, as well as antinociceptive efficacy via dual actions against transient receptor potential vanilloid 1 (TrpV1; IC50/Emax = 1.4 μM/67% against 2 nM RTX for binding mouse spinal cord membranes; IC50/Emax = 40 μM/62% against 20 μM capsaicin-induced mouse spinal cord synaptosomes Ca2+ influx) and cyclooxygenases (IC50 = 16.17 μM/COX1 and 7.76μM/COX2). a-spinasterol can directly affect membrane structure and packing in a manner similar to cholesterol, both a-spinasterol and stitosterol are reported to lower plasma/liver cholesterol levels and increase fecal cholesterol excretion when supplemented in daily diet (1%) in mice in vivo.', 'α-Spinasterol is a constituent of argan oil. It regulates nuclear receptors expression and modulates mitochondrial function. It mimics natural cholesterol and its functionality. α-Spinastero lelicits cytoprotective and antiulcerogenic functionality. It has therapeutic potential towards diabetic nephropathy.

target

TRPV | HMG-CoA reductase

A-SPINASTEROL(481-18-5)Related Product Information

• ALLEOSIDE A
• Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)-
• poricoic acid A 3-methyl ester
• 22,25-Epoxy-2,3,14,20-tetrahydroxycholest-7-en-6-one
• Resibufogenin
• Bufotaline
• (3beta,25R)-14-Hydroxyspirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-xylopyranosyl-(1-4)]-beta-D-glucopyranoside
• Bufalin
• Hydroxyecdysone
• beta-Sitosterol
• Stigmasterol
• A-SPINASTEROL
• 1 19-EICOSADIENE