22(R)-HYDROXYCHOLESTEROL
22(R)-HYDROXYCHOLESTEROL Basic information
- Product Name:
- 22(R)-HYDROXYCHOLESTEROL
- Synonyms:
-
- 22α-Hydroxycholesterol, 5-Cholestene-3β,22(R)-diol, 5-Cholestene-3β,22[R]-diol
- (22R)-Cholest-5-ene-3β,22-diol
- 22R-OHC
- (3beta,22R)-Cholest-5-ene-3,22-diol
- Cholest-5-ene-3,22-diol, (3beta,22R)-
- (20S,22R)-Cholest-5-ene-3β,22-diol
- (3β,22R)-Cholest-5-ene-3,22-diol
- Cholest-5-ene-3β,22(R)-diol
- CAS:
- 17954-98-2
- MF:
- C27H46O2
- MW:
- 402.65
- Product Categories:
-
- Hydroxycholesterol
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Steroids
- Mol File:
- 17954-98-2.mol
22(R)-HYDROXYCHOLESTEROL Chemical Properties
- Melting point:
- 171-174°C
- Boiling point:
- 513.1±23.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 15.01±0.20(Predicted)
- color
- White to Off-White
- InChIKey
- RZPAXNJLEKLXNO-QUOSNDFLSA-N
MSDS
- Language:English Provider:SigmaAldrich
22(R)-HYDROXYCHOLESTEROL Usage And Synthesis
Description
The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-
Uses
The 22R-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.
Uses
Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.
Definition
ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.
General Description
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain.
Biochem/physiol Actions
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand.. 22(R)-HC in combination with other oxysterols promote mesenchymal stem cell osteogenesis. It regulates cholesterol homeostasis. Low levels of 22(R)-HC is observed in Alzheimer′s disease and it may be implicated in neuroinflammation and neurodegenerative diseases. 22(R)-hydroxycholesterol also suppresses prostate tumor progression.
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22(R)-HYDROXYCHOLESTEROL(17954-98-2)Related Product Information
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- 22(R)-HYDROXYCHOLESTEROL
- 5-CHOLESTENE
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