RUSCOGENIN Chemical Properties

Melting point:

198-202℃

Boiling point:

563.1±50.0 °C(Predicted)

Density 

1.18

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

pka

14.56±0.70(Predicted)

form 

Solid

color 

White

Safety Information

Safety Statements 

24/25

HS Code 

29389090

RUSCOGENIN Usage And Synthesis

Chemical Properties

White powder

Uses

A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner.

Definition

ChEBI: Ruscogenin is a triterpenoid.

Biological Activity

Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-KB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.

target

PGE | TNF-α | NF-kB | p65 | NO | NOS | COX | ERK | JNK | Akt | p38MAPK | PKA | cAMP | IL Receptor

RUSCOGENIN(472-11-7)Related Product Information

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