3-Amino-3-iminopropanoic acid ethyl ester hydrochloride Chemical Properties

Melting point:

105-108℃

storage temp. 

Inert atmosphere,Room Temperature

form 

Solid

Appearance

White to light yellow Solid

InChI

InChI=1S/C5H10N2O2.ClH/c1-2-9-5(8)3-4(6)7;/h2-3H2,1H3,(H3,6,7);1H

InChIKey

VOHFLYOSVGWQOS-UHFFFAOYSA-N

SMILES

C(C(OCC)=O)C(N)=N.Cl

3-Amino-3-iminopropanoic acid ethyl ester hydrochloride Usage And Synthesis

Uses

It is used as a pharmaceutical intermediate.

Synthesis

The general procedure for the synthesis of ethyl 3-amidinopropionate hydrochloride from ethyl 3-ethoxy-3-iminopropionate was as follows: ethyl 3-amino-3-ethoxyacrylate (760 mg, 4.78 mmol) and ammonium chloride (270 mg, 5.0 mmol) were dissolved in ethanol (4.0 mL) in a glass tube rated for 10 mL pressure. The reaction was carried out using a CEM Discover microwave synthesizer at an initial magnetron power of 200 W for 1 h at 120°C (hold time). Upon completion of the reaction, the reaction mixture was cooled in a stream of compressed air and subsequently filtered. The filtrate was concentrated by vacuum evaporation and the residue was ground with diethyl ether to afford ethyl 3-amidinopropionate hydrochloride (923 mg, 78% yield) as a colorless solid, which was ready for use without further purification. The product characterization data were as follows: νmax (neat)/ cm-1 3300, 3095, 1738, 1687; δH (500 MHz; d6-DMSO)/ ppm 9.16 (2H, broad single peak, NH2), 8.88 (2H, broad single peak, NH2), 4.15 (2H, quartet peak, J = 7.1 Hz, OCH2), 3.63 (2H, single peak, CH2), 1.22 (3H, triple peak, J = 7.1 Hz, CH3); δC (125 MHz, d6-DMSO)/ ppm 166.7 (C=O), 163.6 (C=N), 61.9 (OCH2), 38.2 (CH2), 14.4 (CH3); m/z (EI) 130 (M-+).

References

[1] Synlett, 2016, vol. 27, # 11, p. 1728 - 1732
[2] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 5, p. 788 - 796
[3] Patent: WO2008/33745, 2008, A2. Location in patent: Page/Page column 70
[4] Patent: WO2008/33747, 2008, A2. Location in patent: Page/Page column 254-255
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 12, p. 6002 - 6014

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