5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL CAS#: 80-92-2

5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Basic information

Product Name:

5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL

Synonyms:

3-alpha,20-alpha-dihydroxy-5-beta-pregnan
3-alpha,20-alpha-dihydroxy-5-beta-pregnane
5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL
5B-PREGNANE-3A,20A-DIOL
5BETA-PREGNAN-3A,20A-DIOL
5-BETA-PREGNAN-3-ALPHA, 20-ALPHA-DIOL
PREGNANEDIOL
PREGNANDIOL

CAS:

80-92-2

MF:

C21H36O2

MW:

320.51

EINECS:

201-313-7

Product Categories:

Inhibitors
Steroids
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals
Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
Biochemistry
Hydroxysteroids

Mol File:

80-92-2.mol

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5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Chemical Properties

Melting point:: 240-242°C
alpha: D20 +27.4° (c = 0.7 in alc)
Boiling point:: 399.39°C (rough estimate)
Density: 1.1500
refractive index: 27 ° (C=0.5, EtOH)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 15.05±0.20(Predicted)
color: White to Off-White
Merck: 7727

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Safety Information

RTECS: TU4157113

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5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL Usage And Synthesis

Chemical Properties

White Solid

Uses

Progesterone metabolite

Uses

5β-Pregnane-3α,20α-diol is a metabolite of Progesterone (P755900).

Uses

Labelled 5β-Pregnane-3α,20α-diol, a metabolite of Progesterone (P755900).

Definition

ChEBI: Pregnanediol is a corticosteroid hormone. It is a tautomer of a 5beta-pregnane-3beta,20alpha-diol.

Purification Methods

Crystallise the diol from acetone. The diacetate [1174-69-2] crystallises from pet ether with m 180o (also 182183o) and [] D 20 +35o (c 1.1, CHCl3). [Marian Biochem J 23 1090 1929, Fish et al. J Biol Chem 143 716 1942, Hieschmann J Biol Chem 140 797 1941, Johnson et al. J Chem Soc 1302 1954, Glick et al. J Org Chem 27 3121 1962, Beillstein 6 III 4778, 6 IV 6111.]

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