Methyl 2-aminothiazole-5-carboxylate Chemical Properties

Melting point:

182-186°C

Boiling point:

298.7±13.0 °C(Predicted)

Density 

1.408±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

3.02±0.10(Predicted)

form 

Solid

color 

Tan to Light Brown

InChI

InChI=1S/C5H6N2O2S/c1-9-4(8)3-2-7-5(6)10-3/h2H,1H3,(H2,6,7)

InChIKey

UJNNCGWBDJHCEM-UHFFFAOYSA-N

SMILES

S1C(C(OC)=O)=CN=C1N

CAS DataBase Reference

6633-61-0(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Harmful

HS Code 

29349990

Methyl 2-aminothiazole-5-carboxylate Usage And Synthesis

Uses

Methyl 2-Aminothiazole-5-carboxylate (cas# 6633-61-0) is a compound useful in organic synthesis.

Synthesis

General procedure for the synthesis of methyl 2-aminothiazole-5-carboxylate from methyl 2-chloro-3-oxopropionate and compound (CAS:17356-08-0): a mixture of 2.4 g of methyl 2-chloro-3-oxopropionate, 20 mL of water, and 1.75 g of thiourea was refluxed for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, decolorized by adding 0.25 g of activated carbon (Norit) and filtered. The filtrate was adjusted to neutral pH by slowly adding 2.5 N sodium hydroxide solution to the filtrate.The precipitate was collected by filtration to give 1.23 g (44% yield) of methyl 2-aminothiazole-5-carboxylate.

References

[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991, # 3, p. 349 - 352
[2] Patent: WO2003/97616, 2003, A1. Location in patent: Page/Page column 26
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 5799
[4] Ann. Rep. Res. Inst. Tuberc. Kanazawa Univ., 1953, vol. 11, # 2, p. 39,41
[5] Chem.Abstr., 1955, p. 8250

Methyl 2-aminothiazole-5-carboxylate(6633-61-0)Related Product Information

• Trimethoxymethane
• Methylparaben
• Bensulfuron methyl
• Methanol
• 2-(2-Aminothiazol-4-yl)glyoxylic acid
• Kresoxim-methyl
• Methyl anthranilate
• METSULFURON METHYL
• 2-Aminothiazole
• 2-AMINOTHIAZOLE-5-CARBOXYLIC ACID
• Methyl 2-bromobenzoate
• Methyl formate
• RESMETHRIN
• Methyl cellulose
• Methyl acrylate
• Methyl benzoate
• Ethyl 2-amino-1,3-thiazole-4-carboxylate
• Ethyl 2-aminothiazole-5-carboxylate