Basic information Safety Supplier Related

K-252B

Basic information Safety Supplier Related

K-252B Basic information

Product Name:
K-252B
Synonyms:
  • PROTEIN KINASE INHIBITOR K-252B
  • K-252B
  • K-252B, NOCARDIOPSIS SP
  • K-252B, NOCARDIOPSIS SPECIES
  • K252B READY MADE
  • k-252b solution
  • Antibiotic K 252b
  • KT 5556
CAS:
99570-78-2
MF:
C26H19N3O5
MW:
453.45
EINECS:
999-999-2
Product Categories:
  • antibiotic
  • Antibiotics G-MSerine/Threonine Kinase Biology
  • Antibiotics
  • Antibiotics A to
  • Protein Kinase C (PKC)
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase
Mol File:
99570-78-2.mol
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K-252B Chemical Properties

Boiling point:
769.8±60.0 °C(Predicted)
Density 
1.78±0.1 g/cm3(Predicted)
storage temp. 
−20°C
form 
ready-to-use solution
pka
3.33±0.40(Predicted)
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Safety Information

Hazard Codes 
Xi
RIDADR 
UN 1993 / PGIII
HS Code 
29349990

MSDS

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K-252B Usage And Synthesis

Description

K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC50 = 0.5 μg/ml) and human basophils. This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.

Chemical Properties

Yellow solid

Uses

K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).

Uses

K 252b, is an antibiotics, and a known protein tyrosine kinase inhibitor. It has been also shown to inhibit the trophic activity of brain-derived neurotrophic factor on dopaminergic (DAergic) neurons and nerve growth factor on basal forebrain cholinergic neurons.

K-252BSupplier

Nanjing Shizhou Biology Technology Co.,Ltd Gold
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025-85560043-
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sean.lv@synzest.com
J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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3bsc@sina.com
Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Email
market@aladdin-e.com