K-252C Chemical Properties

Melting point:

>200°C (dec.)

storage temp. 

−20°C

solubility 

DMSO: 10 mg/mL, soluble

form 

solid

color 

Pale Brown to Light Brown

Water Solubility 

Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water.

Safety Information

Safety Statements 

22-24/25

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich

K-252C Usage And Synthesis

Uses

Inhibits protein kinase C

Biological Activity

Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13-0.32 μ M). Shows no activity against herpes simplex virus (HSV).

storage

-20°C

References

1. fabre s, prudhomme m, rapp m. protein kinase c inhibitors; structure-activity relationships in k252c-related compounds. bioorg med chem 1993,1:193-196.2. hashimoto s. k-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in pc12h cells. j cell biol 1988,107:1531-1539.3. raychaudhuri sp, sanyal m, weltman h, kundu-raychaudhuri s. k252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. j invest dermatol 2004,122:812-819.

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